TGF-β signaling in T cells: roles in lymphoid and epithelial neoplasia (Q29036999)

Europe PubMed Central

title

TGF-β signaling in T cells: roles in lymphoid and epithelial neoplasia (English)

1 reference

27 March 2017

author name string

John J Letterio

series ordinal

1

1 reference

27 March 2017

language of work or name

English

0 references

publication date

29 August 2005

1 reference

27 March 2017

1 reference

27 March 2017

volume

24

1 reference

27 March 2017

issue

37

1 reference

27 March 2017

page(s)

5701-5712

1 reference

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

27 March 2017

cites work

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208922

Signal transduction by the TGF-beta superfamily

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208922

Transforming growth factor-beta induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor protein

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208922

Role of transforming growth factor-beta signaling in cancer

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208922

Regulation of immune responses by TGF-beta

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208922

Cytoplasmic PML function in TGF-beta signalling

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208922

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208922

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208922

Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208922

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208922

Negative regulation of cytokine signaling pathways

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1208922

Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoter

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Cross-talk between interleukin-6 and transforming growth factor-beta3 regulates extracellular matrix production by human fibroblasts from subjects with non-syndromic cleft lip and palate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Role of TGF-beta in immune-evasion of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Suppression of IL-2-induced T cell proliferation and phosphorylation of STAT3 and STAT5 by tumor-derived TGF beta is reversed by IL-15.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Requirement for transforming growth factor beta1 in controlling T cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Transforming growth factor type beta 1 (TGF-beta 1) down-regulates interleukin-2 production and up-regulates interleukin-2 receptor expression in a thymoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Role of transforming growth factor Beta in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

The possible role of TGF-beta-induced suppressors of cytokine signaling expression in osteoclast/macrophage lineage commitment in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

HIV antigens can induce TGF-beta(1)-producing immunoregulatory CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Transforming growth factor-beta in T-cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Signaling through the hematopoietic cytokine receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Role of TGF-beta in cancer and the potential for therapy and prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Tumor-derived TGF-beta reduces the efficacy of dendritic cell/tumor fusion vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

The amount of scurfin protein determines peripheral T cell number and responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

TGF-beta: a critical modulator of immune cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

TGF-beta and vitamin D3 utilize distinct pathways to suppress IL-12 production and modulate rapid differentiation of human monocytes into CD83+ dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Suppressor and oncogenic roles of transforming growth factor-beta and its signaling pathways in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Type beta transforming growth factor: a bifunctional regulator of cellular growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Smad3: a key player in pathogenetic mechanisms dependent on TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Transforming growth factor-beta and the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Signaling mechanisms of cytokine receptors and their perturbances in disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

TGF-beta signaling: positive and negative effects on tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Loss of Smad3 in acute T-cell lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Interleukin-6 regulation of transforming growth factor (TGF)-beta receptor compartmentalization and turnover enhances TGF-beta1 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

Loss of Smad3 modulates wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Biology of TGF-beta in knockout and transgenic mouse models

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Interleukin 7 (murine pre-B cell growth factor/lymphopoietin 1) stimulates thymocyte growth: regulation by transforming growth factor beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Expression of the transforming growth factor beta isoforms in inflammatory cells of nasal polyps

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

TGF-beta signaling, tumor suppression, and acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Contrasting effect of transforming growth factor type beta 1 (TGF-beta 1) on proliferation and interleukin-2 receptor expression in activated and rapidly cycling immature (CD3-CD4-CD8-) thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Inhibitory effects of transforming growth factor-beta (TGF-beta) on certain functions of intraepithelial lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Molecular mechanisms of TGF-(beta) antagonism by interferon (gamma) and cyclosporine A in lung fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Tumor-specific CD4(+) suppressor T-cell clone capable of inhibiting rejection of syngeneic sarcoma in A/J mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Both IL-2 and IL-4 synergize with IL-12 to induce a CTL response, a response completely blocked by TGF-beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Molecular mechanisms behind the dose-dependent differential activation of MAPK pathways induced by transforming growth factor-beta1 in hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Transforming growth factor-beta signaling in normal and malignant hematopoiesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Inducible gene targeting in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Function of cytokines within the TGF-beta superfamily as determined from transgenic and gene knockout studies in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Quiescence of hematopoietic stem cells and maintenance of the stem cell pool is not dependent on TGF-beta signaling in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Maternal rescue of transforming growth factor-beta 1 null mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Transforming growth factor-beta1-deficient mice: identification of isoform-specific activities in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Transforming growth factor-beta pathway serves as a primary tumor suppressor in CD8+ T cell tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Tumor suppressor activity of the TGF-beta pathway in human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

TGF-beta 1 differentially regulates IL-2 expression and [3H]-thymidine incorporation in CD3 epsilon mAb- and CD28 mAb-activated splenocytes and thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Ecsit-ement on the crossroads of Toll and BMP signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Regulation of early chicken thymocyte proliferation by transforming growth factor-beta from thymic stromal cells and thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25- T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

TGF-beta signaling from receptors to the nucleus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Transforming growth factor-beta- and Activin-Smad signaling pathways are activated at distinct maturation stages of the thymopoeisis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Intracellular signaling by growth factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Control of T-cell activation by CD4+ CD25+ suppressor T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Transforming growth factor-beta-mediated down-regulation of antitumor cytotoxicity of spleen cells from MOPC-315 tumor-bearing mice engaged in tumor eradication following low-dose melphalan therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Signal transduction during myeloid cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Smad3 mutant mice develop metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1208922

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1208922

1 reference