Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27) (Q29147438)

4 April 2017

title

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27) (English)

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Enhancer of zeste 2 polycomb repressive complex 2 subunit

4 April 2017

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1 reference

histone methyltransferase activity (H3-K27 specific)

GOA release 2020-03-11

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GOA release 2020-03-11

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Michael T. McCabe

1

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4 April 2017

Alan P. Graves

2

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4 April 2017

Gopinath Ganji

3

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4 April 2017

Elsie Diaz

4

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4 April 2017

Wendy S. Halsey

5

1 reference

4 April 2017

Yong Jiang

6

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4 April 2017

Kimberly N. Smitheman

7

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4 April 2017

Heidi M. Ott

8

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4 April 2017

Melissa B. Pappalardi

9

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4 April 2017

Kimberly E. Allen

10

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4 April 2017

Stephanie B. Chen

11

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4 April 2017

Anthony Della Pietra

12

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4 April 2017

Edward Dul

13

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4 April 2017

Ashley M. Hughes

14

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4 April 2017

Seth A. Gilbert

15

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4 April 2017

Sara H. Thrall

16

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4 April 2017

Peter J. Tummino

17

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4 April 2017

Ryan G. Kruger

18

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4 April 2017

Martin Brandt

19

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4 April 2017

Benjamin Schwartz

20

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4 April 2017

Caretha L. Creasy

21

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4 April 2017

language of work or name

English

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publication date

21 February 2012

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Proceedings of the National Academy of Sciences of the United States of America

4 April 2017

published in

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4 April 2017

volume

109

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4 April 2017

issue

8

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4 April 2017

page(s)

2989–2994

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Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

4 April 2017

cites work

1 reference

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6 April 2017

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7 April 2017

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7 April 2017

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Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

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The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states

7 April 2017

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Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

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Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy

3 June 2018

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EZH2-mediated concordant repression of Wnt antagonists promotes β-catenin-dependent hepatocarcinogenesis.

3 June 2018

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3 June 2018

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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

3 June 2018

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

3 June 2018

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High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients.

3 June 2018

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EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

3 June 2018

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3 June 2018

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The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2.

3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer

3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

3 June 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1116418109

Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1116418109

Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa

21 January 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1116418109

Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22323599

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Abnormal histone acetylation and methylation levels in esophageal squamous cell carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22323599

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Global histone H3 lysine 27 (H3K27) methylation levels and their prognostic relevance in renal cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22323599

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1116418109

1 reference

ADS bibcode

2012PNAS..109.2989M

0 references

1 reference

1 reference

1 reference