Enhancer of zeste 2 polycomb repressive complex 2 subunit (Q21097530)

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mammalian protein found in Homo sapiens
  • lysine N-methyltransferase 6
  • ENX-1
  • enhancer of zeste homolog 2
  • EZH2
  • histone-lysine N-methyltransferase EZH2
  • Enhancer of Zeste Homolog 2 Protein
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Language Label Description Also known as
English
Enhancer of zeste 2 polycomb repressive complex 2 subunit
mammalian protein found in Homo sapiens
  • lysine N-methyltransferase 6
  • ENX-1
  • enhancer of zeste homolog 2
  • EZH2
  • histone-lysine N-methyltransferase EZH2
  • Enhancer of Zeste Homolog 2 Protein

Statements

molecular function
protein binding
determination method
IPI
26 references
retrieved
8 April 2019
stated in
O-GlcNAcylation regulates EZH2 protein stability and function
GOA
curator
UniProt
UniProt protein ID
Q15910
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27
GOA
curator
UniProt
UniProt protein ID
Q15910
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling
GOA
curator
UniProt
UniProt protein ID
Q15910
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome
GOA
curator
UniProt
UniProt protein ID
Q15910
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
A Y2H-seq approach defines the human protein methyltransferase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
The Polycomb group protein EZH2 directly controls DNA methylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
ATRX directs binding of PRC2 to Xist RNA and Polycomb targets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
A High-Density Map for Navigating the Human Polycomb Complexome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
The histone variant macroH2A is an epigenetic regulator of key developmental genes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IPI
cell component
ESC/E(Z) complex
determination method
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IEA
retrieved
8 April 2019
stated in
O-GlcNAcylation regulates EZH2 protein stability and function
GOA
curator
UniProt
UniProt protein ID
Q15910
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IDA
retrieved
8 April 2019
stated in
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
GOA
curator
UniProt
UniProt protein ID
Q15910
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IDA
retrieved
8 April 2019
stated in
An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting
GOA
curator
UniProt
UniProt protein ID
Q15910
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IDA
retrieved
8 April 2019
stated in
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity
GOA
curator
UniProt
UniProt protein ID
Q15910
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IDA
retrieved
8 April 2019
stated in
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15910
determination method
IDA
biological process
Commons category
Enhancer of Zeste Homolog 2
0 references

Identifiers

MeSH descriptor ID
D000071221
subject named as
Enhancer of Zeste Homolog 2 Protein
0 references
RefSeq protein ID
 
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