Frizzled 2 Dmel_CG9739 (Q29810566)

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Protein found in Drosophila melanogaster

frizzled 2
fz2-PA
CG9739-PA
CG9739-PG
D-frizzled2
CG9739-PC
CG9739-PE
frizzled2
fz2-PF
fz2-PC
fz2-PG
fz2-PD
fz2-PB
drosophila frizzled2
frizzled-2
CG9739-PB
DFrizzled2
Dfrizzled[[2]]
CG9739-PF
drosophila frizzled 2
CG9739-PD
CG9739 gene product from transcript CG9739-RG
fz2
fz2-PE

Language	Label	Description	Also known as
English	Frizzled 2 Dmel_CG9739	Protein found in Drosophila melanogaster	frizzled 2 fz2-PA CG9739-PA CG9739-PG D-frizzled2 CG9739-PC CG9739-PE frizzled2 fz2-PF fz2-PC fz2-PG fz2-PD fz2-PB drosophila frizzled2 frizzled-2 CG9739-PB DFrizzled2 Dfrizzled[[2]] CG9739-PF drosophila frizzled 2 CG9739-PD CG9739 gene product from transcript CG9739-RG fz2 fz2-PE

Statements

1 reference

25 May 2022

UniProt protein ID

frizzled/secreted frizzled-related protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VVX3

Frizzled cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VVX3

G protein-coupled receptor

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Frizzled/Smoothened, transmembrane domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 2-like

1 reference

based on heuristic

inferred from protein domain or family

Frizzled domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

signal transducer activity

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVX3&geneProductId=UniProtKB:Q9VVX3

determination method

protein binding

determination method

1 reference

8 April 2019

Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

Wnt-protein binding

determination method

4 references

27 March 2018

Ligand receptor interactions in the Wnt signaling pathway in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVX3&geneProductId=UniProtKB:Q9VVX3

determination method

27 March 2018

Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVX3&geneProductId=UniProtKB:Q9VVX3

determination method

27 March 2018

Roles of N-glycosylation and lipidation in Wg secretion and signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVX3&geneProductId=UniProtKB:Q9VVX3

determination method

27 March 2018

A new member of the frizzled family from Drosophila functions as a Wingless receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVX3&geneProductId=UniProtKB:Q9VVX3

determination method

PDZ domain binding

determination method

1 reference

8 April 2019

Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

identical protein binding

determination method

1 reference

8 April 2019

Hedgehog regulates smoothened activity by inducing a conformational switch

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

Wnt-activated receptor activity

determination method

4 references

27 March 2018

Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVX3&geneProductId=UniProtKB:Q9VVX3

determination method

27 March 2018

A new member of the frizzled family from Drosophila functions as a Wingless receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVX3&geneProductId=UniProtKB:Q9VVX3

determination method

27 March 2018

Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVX3&geneProductId=UniProtKB:Q9VVX3

determination method

27 March 2018

Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVX3&geneProductId=UniProtKB:Q9VVX3

determination method

G protein-coupled receptor activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

Wnt-protein binding

determination method

5 references

8 April 2019

Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Roles of N-glycosylation and lipidation in Wg secretion and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Ligand receptor interactions in the Wnt signaling pathway in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

A new member of the frizzled family from Drosophila functions as a Wingless receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

Wnt-activated receptor activity

determination method

5 references

8 April 2019

Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

A new member of the frizzled family from Drosophila functions as a Wingless receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

determination method

1 reference

8 April 2019

Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

determination method

1 reference

8 April 2019

Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

determination method

1 reference

8 April 2019

Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

plasma membrane

determination method

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVX3&geneProductId=UniProtKB:Q9VVX3

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVX3&geneProductId=UniProtKB:Q9VVX3

determination method

27 March 2018

Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VVX3&geneProductId=UniProtKB:Q9VVX3

determination method

determination method

2 references

integral component of membrane

determination method

4 references

8 April 2019

A new member of the frizzled family from Drosophila functions as a Wingless receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Drosophila melanogaster G protein-coupled receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

plasma membrane

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

biological process

signal transduction

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

cell surface receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

determination method

1 reference

8 April 2019

Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

salivary gland morphogenesis

determination method

1 reference

8 April 2019

Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

motor neuron axon guidance

determination method

1 reference

8 April 2019

Wnt4 is a local repulsive cue that determines synaptic target specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

female gonad development

determination method

1 reference

8 April 2019

DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

synaptic target inhibition

determination method

1 reference

8 April 2019

Wnt4 is a local repulsive cue that determines synaptic target specificity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

determination method

1 reference

8 April 2019

DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

retinal ganglion cell axon guidance

determination method

1 reference

8 April 2019

DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

regulation of hemocyte proliferation

determination method

1 reference

8 April 2019

Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

chitin-based larval cuticle pattern formation

determination method

1 reference

8 April 2019

The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

non-canonical Wnt signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

determination method

1 reference

8 April 2019

A signaling network for patterning of neuronal connectivity in the Drosophila brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

synapse organization

determination method

1 reference

8 April 2019

Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

canonical Wnt signaling pathway

determination method

6 references

8 April 2019

The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

A new member of the frizzled family from Drosophila functions as a Wingless receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VVX3

determination method

Frizzled/Smoothened, transmembrane domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VVX3

GPCR, family 2-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VVX3

frizzled domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9VVX3

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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