Expanded Dmel_CG4114 (Q29812380)

http://www.ebi.ac.uk/interpro/protein/Q07436

PH-like domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07436

FERM superfamily, second domain

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q07436

Band 4.1 domain, protein family

1 reference

FERM central domain, protein family

1 reference

FERM, C-terminal PH-like domain, protein family

1 reference

FERM domain, protein family

1 reference

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

transcription factor binding

1 reference

8 April 2019

The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

1 reference

8 April 2019

Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

Control of growth and organ size in Drosophila

apical plasma membrane

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

1 January 2018

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

1 reference

1 January 2018

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

1 reference

8 April 2019

Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

IDA

apical plasma membrane

1 reference

8 April 2019

cytoplasmic side of apical plasma membrane

4 references

8 April 2019

Kibra is a regulator of the Salvador/Warts/Hippo signaling network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

transcription, DNA-templated

IDA

biological process

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

regulation of transcription, DNA-templated

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

regulation of exit from mitosis

1 reference

8 April 2019

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

multicellular organism development

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

border follicle cell migration

1 reference

8 April 2019

The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

negative regulation of cell population proliferation

IMP

5 references

8 April 2019

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

regulation of signal transduction

1 reference

8 April 2019

The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

ovarian follicle cell development

1 reference

8 April 2019

A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

1 reference

8 April 2019

The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

4 references

1 January 2018

Vamana Couples Fat Signaling to the Hippo Pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

1 January 2018

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

1 January 2018

Fat and expanded act in parallel to regulate growth through warts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

1 January 2018

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

regulation of hippo signaling

1 reference

1 January 2018

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

negative regulation of hippo signaling

IMP

positive regulation of phosphorylation

IPI

1 reference

1 January 2018

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

regulation of apoptotic process

1 reference

1 January 2018

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

negative regulation of imaginal disc growth

4 references

1 January 2018

Control of growth and organ size in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

1 January 2018

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

1 January 2018

Zyxin links fat signaling to the hippo pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

1 January 2018

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

regulation of cell differentiation

1 reference

8 April 2019

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

negative regulation of transcription, DNA-templated

1 reference

1 January 2018

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

regulation of organ growth

IDA

1 reference

1 January 2018

Fat and expanded act in parallel to regulate growth through warts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07436&geneProductId=UniProtKB:Q07436

negative regulation of organ growth

3 references

8 April 2019

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

Fat and expanded act in parallel to regulate growth through warts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

positive regulation of hippo signaling

12 references

8 April 2019

The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The WW domain protein Kibra acts upstream of Hippo in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

Fat and expanded act in parallel to regulate growth through warts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

In vivo regulation of Yorkie phosphorylation and localization.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

1 reference

8 April 2019

Genes affecting cell competition in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

negative regulation of imaginal disc growth

3 references

8 April 2019

The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

Zyxin links fat signaling to the hippo pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436

8 April 2019

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07436