The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis (Q34474913)

2 August 2017

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis (English)

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2 August 2017

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GOA release 2020-03-11

Expanded Dmel_CG4114

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GOA release 2020-03-11

Yorkie Dmel_CG4005

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GOA release 2020-03-11

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Georg Halder

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Fisun Hamaratoglu

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Maria Willecke

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Madhuri Kango-Singh

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Riitta Nolo

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Eric Hyun

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Chunyao Tao

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Hamed Jafar-Nejad

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11 December 2005

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27-36

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https://scigraph.springernature.com/pub.10.1038/ncb1339

2 August 2017

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cites work

Control of growth and organ size in Drosophila

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Size control in animal development

21 January 2018

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21 January 2018

The Hallmarks of Cancer

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Hippo and its mission for growth control

21 January 2018

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Coupling cell growth, proliferation, and death. Hippo weighs in.

21 January 2018

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Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

21 January 2018

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The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

21 January 2018

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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

21 January 2018

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

21 January 2018

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The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis

21 January 2018

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salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

21 January 2018

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Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

21 January 2018

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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

21 January 2018

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Control of cell proliferation and apoptosis by mob as tumor suppressor, mats

21 January 2018

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The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

21 January 2018

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The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

21 January 2018

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Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

21 January 2018

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A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

21 January 2018

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Merlin and ERM proteins: unappreciated roles in cancer development?

21 January 2018

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Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

21 January 2018

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NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

21 January 2018

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NF2: the wizardry of merlin

21 January 2018

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ERM proteins and merlin: integrators at the cell cortex

21 January 2018

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Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L

21 January 2018

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Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization

21 January 2018

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The Drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during development.

21 January 2018

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Cell proliferation, survival, and death in the Drosophila eye.

21 January 2018

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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

21 January 2018

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The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

21 January 2018

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Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death

21 January 2018

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Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

21 January 2018

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

21 January 2018

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Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

21 January 2018

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The Ste20 group kinases as regulators of MAP kinase cascades

21 January 2018

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Organizing activity of wingless protein in Drosophila.

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/NCB1339

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Dimensions Publication ID

2 August 2017

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