Neuralized Dmel_CG11988 (Q29813856)

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Protein found in Drosophila melanogaster

CG11988-PB
CG11988-PA
CG11988-PD
neur-PC
CG11988-PC
neur-PE
neur-PB
neur-PA
neuralised
neur
CG11988-PE
CG11988 gene product from transcript CG11988-RD
neuralized
neur-PD

Language	Label	Description	Also known as
English	Neuralized Dmel_CG11988	Protein found in Drosophila melanogaster	CG11988-PB CG11988-PA CG11988-PD neur-PC CG11988-PC neur-PE neur-PB neur-PA neuralised neur CG11988-PE CG11988 gene product from transcript CG11988-RD neuralized neur-PD

Statements

1 reference

25 May 2022

UniProt protein ID

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29503

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29503

Neuralized homology repeat (NHR) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

ubiquitin-protein transferase activity

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

zinc ion binding

determination method

1 reference

1 January 2018

Comprehensively surveying structure and function of RING domains from Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

metal ion binding

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

ubiquitin protein ligase activity

determination method

3 references

1 January 2018

Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

1 January 2018

Neuralized functions as an E3 ubiquitin ligase during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

1 January 2018

Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

phosphatidylinositol phosphate binding

determination method

1 reference

1 January 2018

Neuralized contains a phosphoinositide-binding motif required downstream of ubiquitination for delta endocytosis and notch signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

determination method

1 reference

1 January 2018

The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

plasma membrane

determination method

4 references

1 January 2018

Neuralized functions cell autonomously to regulate Drosophila sense organ development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

1 January 2018

The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

1 January 2018

Neuralized functions as an E3 ubiquitin ligase during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

1 January 2018

Neuralized contains a phosphoinositide-binding motif required downstream of ubiquitination for delta endocytosis and notch signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

perinuclear region of cytoplasm

determination method

1 reference

1 January 2018

Unequal segregation of Neuralized biases Notch activation during asymmetric cell division

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

biological process

protein polyubiquitination

determination method

1 reference

1 January 2018

Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

inter-male aggressive behavior

determination method

1 reference

1 January 2018

Mutations in many genes affect aggressive behavior in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

multicellular organism development

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

ectoderm development

determination method

1 reference

1 January 2018

A role for the Drosophila neurogenic genes in mesoderm differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

nervous system development

determination method

3 references

1 January 2018

Cell fate specification in the Drosophila retina

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

1 January 2018

neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult Drosophila development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

ventral cord development

determination method

1 reference

1 January 2018

Novel Genes Involved in Controlling Specification of Drosophila FMRFamide Neuropeptide Cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

sensory organ development

determination method

1 reference

1 January 2018

Neuralized functions cell autonomously to regulate Drosophila sense organ development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

imaginal disc-derived wing morphogenesis

determination method

1 reference

1 January 2018

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

mesoderm development

determination method

1 reference

1 January 2018

A role for the Drosophila neurogenic genes in mesoderm differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

long-term memory

determination method

1 reference

1 January 2018

Neuralized is expressed in the alpha/beta lobes of adult Drosophila mushroom bodies and facilitates olfactory long-term memory formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

protein localization

determination method

1 reference

1 January 2018

Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

regulation of Notch signaling pathway

determination method

1 reference

1 January 2018

Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

sensory organ precursor cell fate determination

determination method

3 references

1 January 2018

Neuralized functions cell autonomously to regulate Drosophila sense organ development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

1 January 2018

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

1 January 2018

Polarized endosome dynamics by spindle asymmetry during asymmetric cell division

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

cell differentiation

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

ovarian follicle cell development

determination method

1 reference

1 January 2018

Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

germ-line stem cell population maintenance

determination method

1 reference

1 January 2018

Stem cells signal to the niche through the Notch pathway in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

negative regulation of lamellocyte differentiation

determination method

1 reference

1 January 2018

An unexpected link between notch signaling and ROS in restricting the differentiation of hematopoietic progenitors in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

olfactory behavior

determination method

1 reference

1 January 2018

Dynamic genetic interactions determine odor-guided behavior in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

regulation of compound eye photoreceptor development

determination method

1 reference

1 January 2018

The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

lateral inhibition

determination method

1 reference

1 January 2018

Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

regulation of photoreceptor cell differentiation

determination method

1 reference

1 January 2018

The roles of cis-inactivation by Notch ligands and of neuralized during eye and bristle patterning in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

protein homooligomerization

determination method

1 reference

1 January 2018

Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29503&geneProductId=UniProtKB:P29503

determination method

Neuralized homology repeat (NHR) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29503

Zinc finger, RING-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29503

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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