Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling. (Q39263928)

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English	Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling.	scientific article

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10 March 2020

Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling (English)

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10 March 2020

protein ubiquitination

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based on heuristic

inferred from title

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10 March 2020

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Sili Liu

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10 March 2020

Julia Maeve Bonner

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10 March 2020

Cosimo Commisso

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10 March 2020

Lara C Skwarek

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10 March 2020

François Schweisguth

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10 March 2020

Gabrielle L Boulianne

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8 October 2012

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10 March 2020

Molecular and Cellular Biology

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10 March 2020

4933-4945

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10 March 2020

Neurl4, a novel daughter centriole protein, prevents formation of ectopic microtubule organizing centres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Notch ligand ubiquitylation: what is it good for?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Neuralized promotes basal to apical transcytosis of delta in epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Structural and functional characterization of the NHR1 domain of the Drosophila neuralized E3 ligase in the notch signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

RING domain E3 ubiquitin ligases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

The molecular logic of Notch signaling--a structural and biochemical perspective.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Notch signalling: a simple pathway becomes complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Regulation of Notch signalling by endocytosis and endosomal sorting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Mind bomb 1 is essential for generating functional Notch ligands to activate Notch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

A novel inflammation-induced ubiquitin E3 ligase in alveolar type II cells

1 reference

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10 September 2017

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

The roles of receptor and ligand endocytosis in regulating Notch signaling

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Variations on the Notch pathway in neural development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

The structural basis for the recognition of diverse receptor sequences by TRAF2

1 reference

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10 September 2017

Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Jagged: a mammalian ligand that activates Notch1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Neural-specific carbohydrate moiety shared by many surface glycoproteins in Drosophila and grasshopper embryos.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

10 September 2017

Neuralized functions cell autonomously to regulate Drosophila sense organ development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

14 September 2017

Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

25 September 2017

Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell.

1 reference

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25 September 2017

Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture

1 reference

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15 June 2018

The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

15 June 2018

Interaction of master mind, big brain, neuralized and Notch genes of Drosophila melanogaster as expressed in adult morphology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

15 June 2018

The function of the neurogenic genes during epithelial development in the Drosophila embryo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

15 June 2018

Regulation of epithelial polarity by the E3 ubiquitin ligase Neuralized and the Bearded inhibitors in Drosophila.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

21 August 2018

Neuralized contains a phosphoinositide-binding motif required downstream of ubiquitination for delta endocytosis and notch signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

21 August 2018

Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

21 August 2018

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

21 August 2018

Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

21 August 2018

Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila.

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21 August 2018

Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch.

1 reference

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21 August 2018

Unequal segregation of Neuralized biases Notch activation during asymmetric cell division

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

21 August 2018

neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

21 August 2018

Neuralized functions as an E3 ubiquitin ligase during Drosophila development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

21 August 2018

neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult Drosophila development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

21 August 2018

The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

21 August 2018

A role for the Drosophila neurogenic genes in mesoderm differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510530

21 August 2018

On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster

1 reference

https://pubmed.ncbi.nlm.nih.gov/23045391

12 December 2020

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10.1128/MCB.00711-12

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10 March 2020

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10 March 2020

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