G protein-coupled receptor kinase 2 Dmel_CG17998 (Q29814015)

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Protein found in Drosophila melanogaster

nosh
Gprk2-PA
G protein-coupled receptor kinase 2
CG17998 gene product from transcript CG17998-RA
Gprk2
Gprk2-PB
CG17998-PB
CG17998-PA

Language	Label	Description	Also known as
English	G protein-coupled receptor kinase 2 Dmel_CG17998	Protein found in Drosophila melanogaster	nosh Gprk2-PA G protein-coupled receptor kinase 2 CG17998 gene product from transcript CG17998-RA Gprk2 Gprk2-PB CG17998-PB CG17998-PA

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32866

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32866

RGS domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32866

Regulator of G protein signalling

1 reference

based on heuristic

inferred from protein domain or family

AGC-kinase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

protein kinase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

protein serine/threonine kinase activity

determination method

6 references

8 April 2019

Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

8 April 2019

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

8 April 2019

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

8 April 2019

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

G protein-coupled receptor kinase activity

determination method

determination method

2 references

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

phosphatidylinositol-4-phosphate binding

determination method

1 reference

8 April 2019

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

determination method

1 reference

8 April 2019

The Drosophila G-protein-coupled receptor kinase homologue Gprk2 is required for egg morphogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

cytoplasmic side of plasma membrane

determination method

1 reference

8 April 2019

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

biological process

apical constriction involved in gastrulation

determination method

1 reference

8 April 2019

Gprk2 adjusts Fog signaling to organize cell movements in Drosophila gastrulation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

positive regulation of antibacterial peptide biosynthetic process

determination method

1 reference

8 April 2019

Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

imaginal disc-derived wing morphogenesis

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

positive regulation of cAMP-mediated signaling

determination method

1 reference

8 April 2019

Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

positive regulation of Toll signaling pathway

determination method

negative regulation of smoothened signaling pathway

determination method

1 reference

8 April 2019

Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

positive regulation of smoothened signaling pathway

determination method

5 references

8 April 2019

Regulation of smoothened by Drosophila G-protein-coupled receptor kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

8 April 2019

The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

8 April 2019

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

8 April 2019

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

8 April 2019

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

positive regulation of receptor-mediated endocytosis

determination method

1 reference

8 April 2019

Regulation of smoothened by Drosophila G-protein-coupled receptor kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

oocyte morphogenesis

determination method

1 reference

8 April 2019

The Drosophila G-protein-coupled receptor kinase homologue Gprk2 is required for egg morphogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

defense response to Gram-positive bacterium

determination method

1 reference

8 April 2019

Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32866

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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