Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases. (Q50043204)

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16 March 2020

title

Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases (English)

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16 March 2020

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Hedgehog Dmel_CG4637

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SMAD specific E3 ubiquitin protein ligase Dmel_CG4943

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Suppressor of deltex Dmel_CG4244

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G protein-coupled receptor kinase 2 Dmel_CG17998

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Nedd4 Dmel_CG42279

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author

Shuang Li

1

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16 March 2020

Bing Wang

3

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16 March 2020

Jin Jiang

4

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16 March 2020

author name string

Shuangxi Li

2

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16 March 2020

publication date

6 February 2018

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16 March 2020

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16 March 2020

volume

11

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16 March 2020

issue

516

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The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

16 March 2020

cites work

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12 December 2020

Protein kinases that phosphorylate activated G protein-coupled receptors.

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12 December 2020

Protein kinase A and hedgehog signaling in Drosophila limb development

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12 December 2020

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings

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Dual roles for patched in sequestering and transducing Hedgehog

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Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

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brinker is a target of Dpp in Drosophila that negatively regulates Dpp-dependent genes.

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Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

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The sonic hedgehog-patched-gli pathway in human development and disease

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The Hedgehog and Wnt signalling pathways in cancer

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A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.

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Hedgehog signaling in animal development: paradigms and principles

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GAL4 system in Drosophila: a fly geneticist's Swiss army knife

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Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells.

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12 December 2020

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

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12 December 2020

dSmurf Selectively Degrades Decapentaplegic-activated MAD, and Its Overexpression Disrupts Imaginal Disc Development

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12 December 2020

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

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12 December 2020

Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction

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12 December 2020

Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein.

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12 December 2020

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

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12 December 2020

Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins

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12 December 2020

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

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12 December 2020

Vertebrate Smoothened functions at the primary cilium

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12 December 2020

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway

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12 December 2020

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

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12 December 2020

A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.

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12 December 2020

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

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12 December 2020

The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover

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12 December 2020

The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila.

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12 December 2020

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

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12 December 2020

Patched1 regulates hedgehog signaling at the primary cilium

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12 December 2020

Hedgehog regulates smoothened activity by inducing a conformational switch

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12 December 2020

Using immunoprecipitation to study protein-protein interactions in the Hedgehog-signaling pathway.

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12 December 2020

Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor

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12 December 2020

Hedgehog signaling in development and cancer.

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12 December 2020

Intestinal stem cells in mammals and Drosophila

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12 December 2020

Regulation of smoothened by Drosophila G-protein-coupled receptor kinases

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12 December 2020

Mechanism and evolution of cytosolic Hedgehog signal transduction

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12 December 2020

Self-Induced Patched Receptor Down-Regulation Modulates Cell Sensitivity to the Hedgehog Morphogen Gradient

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12 December 2020

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

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12 December 2020

Role of the Drosophila non-visual ß-arrestin kurtz in hedgehog signalling.

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12 December 2020

Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened

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12 December 2020

Gli proteins in development and disease

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12 December 2020

USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization

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12 December 2020

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila

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12 December 2020

Decoding the phosphorylation code in Hedgehog signal transduction

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12 December 2020

The mechanisms of Hedgehog signalling and its roles in development and disease

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12 December 2020

Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling

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12 December 2020

Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover

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12 December 2020

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

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12 December 2020

Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation

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12 December 2020

Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex.

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12 December 2020

Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases

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12 December 2020

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.

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12 December 2020

Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway

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12 December 2020

SUMO regulates the activity of Smoothened and Costal-2 in Drosophila Hedgehog signaling

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12 December 2020

10.1126/SCISIGNAL.AAN8660

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438012%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29438012%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

PubMed publication ID

29438012

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