Smoothened Dmel_CG11561 (Q29814209)

transmembrane signaling receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

G protein-coupled receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 references

8 April 2019

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

A large complex containing Patched and Smoothened initiates Hedgehog signaling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

Wnt-activated receptor activity

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

protein homodimerization activity

1 reference

8 April 2019

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

phosphatidylinositol-4-phosphate binding

IDA

1 reference

8 April 2019

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

1 reference

7 November 2018

Regulation of Hedgehog signaling: a complex story

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

integral component of plasma membrane

1 reference

10 September 2018

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

2 references

integral component of membrane

4 references

10 September 2018

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

10 September 2018

Drosophila melanogaster G protein-coupled receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

integral component of plasma membrane

3 references

8 April 2019

Regulation of smoothened by Drosophila G-protein-coupled receptor kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

Bolwig's organ morphogenesis

IDA

biological process

1 reference

8 April 2019

Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes

mucosal immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

cell surface receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

1 reference

8 April 2019

G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

smoothened signaling pathway

4 references

21 June 2018

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

21 June 2018

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

21 June 2018

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

regulation of mitotic cell cycle

1 reference

8 April 2019

Hedgehog acts as a somatic stem cell factor in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

blastoderm segmentation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

eye-antennal disc morphogenesis

1 reference

8 April 2019

A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

ovarian follicle cell development

IGI

1 reference

1 January 2018

BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

somatic stem cell population maintenance

1 reference

8 April 2019

BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

non-canonical Wnt signaling pathway

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

regulation of apoptotic process

1 reference

8 April 2019

Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

negative regulation of Notch signaling pathway

IGI

1 reference

10 September 2018

Dampening the signals transduced through hedgehog via microRNA miR-7 facilitates notch-induced tumourigenesis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

anterior/posterior lineage restriction, imaginal disc

IGI

1 reference

8 April 2019

Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

wing disc anterior/posterior pattern formation

TAS

1 reference

8 April 2019

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

1 reference

8 April 2019

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

canonical Wnt signaling pathway

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

positive regulation of protein localization to plasma membrane

1 reference

8 April 2019

Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

negative regulation of G1/S transition of mitotic cell cycle

IDA

1 reference

8 April 2019

Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

Wnt signaling pathway

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

smoothened signaling pathway

5 references

10 September 2018

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

10 September 2018

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

10 September 2018

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P91682&geneProductId=UniProtKB:P91682

central nervous system development

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

positive regulation of smoothened signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

commissural neuron axon guidance

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

smoothened signaling pathway

11 references

8 April 2019

Dual roles for patched in sequestering and transducing Hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

Regulation of smoothened by Drosophila G-protein-coupled receptor kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

Identification of a Functional Interaction between the Transmembrane Protein Smoothened and the Kinesin-Related Protein Costal2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

segment polarity determination

1 reference

8 April 2019

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

imaginal disc-derived wing morphogenesis

1 reference

8 April 2019

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P91682

Frizzled/Smoothened, transmembrane domain

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P91682

GPCR, family 2-like

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P91682

frizzled domain

1 reference

stated in

InterPro Release 71.0