USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization (Q34130136)

31 July 2017

title

USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization (English)

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31 July 2017

main subject

Smoothened Dmel_CG11561

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Protein kinase, cAMP-dependent, catalytic subunit 1 Dmel_CG4379

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

protein ubiquitination

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Ruohan Xia

1

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31 July 2017

Hongge Jia

2

1 reference

31 July 2017

Junkai Fan

3

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31 July 2017

Yajuan Liu

4

1 reference

31 July 2017

Jianhang Jia

5

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31 July 2017

language of work or name

English

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publication date

10 January 2012

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31 July 2017

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31 July 2017

volume

10

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31 July 2017

issue

1

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31 July 2017

page(s)

e1001238

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Creative Commons Attribution 4.0 International

31 July 2017

copyright license

start time

10 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling

5 July 2018

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5 July 2018

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The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway.

5 July 2018

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5 July 2018

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Extensive phosphorylation of Smoothened in Hedgehog pathway activation

5 July 2018

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Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

5 July 2018

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5 July 2018

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5 July 2018

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Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2

5 July 2018

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Hrs mediates downregulation of multiple signalling receptors in Drosophila

5 July 2018

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Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail

5 July 2018

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Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

5 July 2018

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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

5 July 2018

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Sonic hedgehog induces the segregation of patched and smoothened in endosomes

5 July 2018

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5 July 2018

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5 July 2018

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Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons

5 July 2018

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Protein regulation by monoubiquitin

5 July 2018

1 reference

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Themes and variations on ubiquitylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254663

In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene

5 July 2018

1 reference

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Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

5 July 2018

1 reference

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Comparative genomics of the eukaryotes

5 July 2018

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UBPY: a growth-regulated human ubiquitin isopeptidase.

5 July 2018

1 reference

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The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254663

The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254663

Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1001238

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

21 January 2018

1 reference

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https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1001238

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.1001238

Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3254663

10.1371/JOURNAL.PBIO.1001238

28 October 2018

Identifiers

DOI

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31 July 2017

1 reference

31 July 2017

1 reference