Polo Dmel_CG12306 (Q29816868)

POLO box domain superfamily

1 reference

First polo-box domain, protein family

1 reference

POLO box domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Second polo-box domain, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

1 January 2018

Protein kinases and phosphatases in the Drosophila genome

IEA

protein kinase activity

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

A conserved mitotic kinase active at late anaphase-telophase in syncytial Drosophila embryos

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

protein serine/threonine kinase activity

3 references

1 January 2018

polo encodes a protein kinase homolog required for mitosis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

The conserved mitotic kinase polo is regulated by phosphorylation and has preferred microtubule-associated substrates in Drosophila embryo extracts

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

4 references

1 January 2018

Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 reference

1 January 2018

Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 reference

1 January 2018

Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

3 references

1 January 2018

Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

The POLO kinase is required at multiple stages during spermatogenesis in Drosophila melanogaster.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

3 references

1 January 2018

Heterologous expression of mammalian Plk1 in Drosophila reveals divergence from Polo during late mitosis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

The POLO kinase is required at multiple stages during spermatogenesis in Drosophila melanogaster.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells

kinetochore microtubule

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 reference

1 January 2018

Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

3 references

1 January 2018

A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Heterologous expression of mammalian Plk1 in Drosophila reveals divergence from Polo during late mitosis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells

mitotic spindle midzone

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

4 references

1 January 2018

polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Regulation of microtubule assembly and organization in mitosis by the AAA+ ATPase Pontin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

actomyosin contractile ring assembly

IGI

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

Protein kinases and phosphatases in the Drosophila genome

protein phosphorylation

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 January 2018

Cell cycle regulation of Greatwall kinase nuclear localization facilitates mitotic progression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 reference

1 January 2018

Identification of Drosophila gene products required for phagocytosis of Candida albicans

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

spindle assembly involved in female meiosis II

1 reference

1 January 2018

Failure of pronuclear migration and repeated divisions of polar body nuclei associated with MTOC defects in polo eggs of Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 reference

1 January 2018

A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

male meiosis cytokinesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

male meiotic nuclear division

1 reference

1 January 2018

polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

female meiotic nuclear division

1 reference

1 January 2018

Interaction between Polo and BicD proteins links oocyte determination and meiosis control in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 reference

1 January 2018

Failure of pronuclear migration and repeated divisions of polar body nuclei associated with MTOC defects in polo eggs of Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 reference

1 January 2018

Failure of pronuclear migration and repeated divisions of polar body nuclei associated with MTOC defects in polo eggs of Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

negative regulation of neuroblast proliferation

1 reference

1 January 2018

Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 reference

1 January 2018

Light, flies and cell division. Workshop: regulation of cell division in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

male germline ring canal formation

IEA

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

astral microtubule nucleation

1 reference

1 January 2018

Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

Failure of pronuclear migration and repeated divisions of polar body nuclei associated with MTOC defects in polo eggs of Drosophila.

sperm aster formation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

1 reference

1 January 2018

Failure of pronuclear migration and repeated divisions of polar body nuclei associated with MTOC defects in polo eggs of Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

embryonic heart tube development

1 reference

1 January 2018

Two forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

Polo-mediated phosphorylation of Maelstrom regulates oocyte determination during oogenesis in Drosophila

oocyte fate commitment

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

meiotic spindle midzone assembly

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

attachment of mitotic spindle microtubules to kinetochore

1 reference

1 January 2018

POLO ensures chromosome bi-orientation by preventing and correcting erroneous chromosome-spindle attachments.

GOA

curator

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P52304&geneProductId=UniProtKB:P52304

has part(s)

First polo-box domain

1 reference

POLO box domain

1 reference

protein kinase domain

1 reference

Second polo-box domain

1 reference

serine/threonine-protein kinase, active site

1 reference