Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases (Q30009098)

21 May 2017

title

Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases (English)

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21 May 2017

Michela Silacci

1

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21 May 2017

Wibke Lembke

2

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21 May 2017

Richard Woods

3

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21 May 2017

Isabella Attinger-Toller

4

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21 May 2017

Nadja Baenziger-Tobler

5

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21 May 2017

Sarah Batey

6

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21 May 2017

Roger Santimaria

7

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21 May 2017

Ulrike von der Bey

8

1 reference

21 May 2017

Susann Koenig-Friedrich

9

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21 May 2017

Wenjuan Zha

10

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21 May 2017

Bernd Schlereth

11

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21 May 2017

Mathias Locher

12

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21 May 2017

Julian Bertschinger

13

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21 May 2017

Dragan Grabulovski

14

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21 May 2017

language of work or name

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22 September 2015

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21 May 2017

published in

Monoclonal Antibodies

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21 May 2017

volume

8

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21 May 2017

issue

1

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21 May 2017

page(s)

141-149

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A bispecific HER2-targeting FynomAb with superior antitumor activity and novel mode of action

21 May 2017

cites work

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Linker length matters, fynomer-Fc fusion with an optimized linker displaying picomolar IL-17A inhibition potency

22 May 2017

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Interleukin 17 contributes to the chronicity of inflammatory diseases such as rheumatoid arthritis

22 May 2017

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EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update

22 May 2017

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Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones

22 May 2017

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Generation, characterization and structural data of chymase binding proteins based on the human Fyn kinase SH3 domain

22 May 2017

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Bispecific antibodies for cancer immunotherapy: Current perspectives

22 May 2017

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Structure of IL-17A in complex with a potent, fully human neutralizing antibody

22 May 2017

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A novel, non-immunogenic Fyn SH3-derived binding protein with tumor vascular targeting properties

22 May 2017

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Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study

22 May 2017

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Remission in rheumatoid arthritis: benefit over low disease activity in patient-reported outcomes and costs

3 June 2018

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3 June 2018

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Treatment options in patients with rheumatoid arthritis failing initial TNF inhibitor therapy: a critical review

3 June 2018

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Selection of single domain binding proteins by covalent DNA display

3 June 2018

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Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: a randomised clinical trial

3 June 2018

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Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate

3 June 2018

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Design and use of phage display libraries for the selection of antibodies and enzymes

3 June 2018

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To switch or to change class-the biologic dilemma in rheumatoid arthritis.

3 June 2018

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Incomplete response of inflammatory arthritis to TNFα blockade is associated with the Th17 pathway.

21 January 2018

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Anti-inflammatory and cartilage-protecting effects of an intra-articularly injected anti-TNF{alpha} single-chain Fv antibody (ESBA105) designed for local therapeutic use.

21 January 2018

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Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.

21 January 2018

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Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: Rationale for combination treatment during arthritis

21 January 2018

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12 December 2020

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys

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12 December 2020

Combined inhibition of tumor necrosis factor α and interleukin-17 as a therapeutic opportunity in rheumatoid arthritis: development and characterization of a novel bispecific antibody

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PubMed

12 December 2020

Treatment of malignant ascites with a second cycle of catumaxomab in gastric signet cell carcinoma--a report of 2 cases

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12 December 2020

10.1080/19420862.2015.1093266

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4795912

OpenCitations bibliographic resource ID

4795912

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4795912

PMC publication ID

4966518

0 references

1 reference