An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin (Q30153240)

15 October 2017

An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin (English)

1 reference

15 October 2017

5

1 reference

15 October 2017

Craig J Morton

4

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author name string

Kristin R Wade

1

1 reference

15 October 2017

Eileen M Hotze

2

1 reference

15 October 2017

Michael J Kuiper

3

1 reference

15 October 2017

Rodney K Tweten

6

1 reference

15 October 2017

language of work or name

English

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publication date

2 February 2015

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Proceedings of the National Academy of Sciences of the United States of America

15 October 2017

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15 October 2017

112

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15 October 2017

7

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15 October 2017

2204-2209

1 reference

A new model for pore formation by cholesterol-dependent cytolysins

15 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration

3 June 2018

1 reference

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Disulfide-bond scanning reveals assembly state and β-strand tilt angle of the PFO β-barrel

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus α-hemolysin

3 June 2018

1 reference

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Identification and characterization of the first cholesterol-dependent cytolysins from Gram-negative bacteria

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Crystal structure of the octameric pore of staphylococcal γ-hemolysin reveals the β-barrel pore formation mechanism by two components

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Membrane assembly of the cholesterol-dependent cytolysin pore complex

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Salt bridges: geometrically specific, designable interactions

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Pore formation by Vibrio cholerae cytolysin follows the same archetypical mode as beta-barrel toxins from gram-positive organisms

3 June 2018

1 reference

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The MACPF/CDC family of pore-forming toxins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Scalable molecular dynamics with NAMD

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Structural basis of pore formation by the bacterial toxin pneumolysin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

UCSF Chimera--a visualization system for exploratory research and analysis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit beta-strand alignment.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Close-range electrostatic interactions in proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Relationship between ion pair geometries and electrostatic strengths in proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Quantitative evaluation of the lengths of homobifunctional protein cross-linking reagents used as molecular rulers

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediate

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Interactions between residues in staphylococcal alpha-hemolysin revealed by reversion mutagenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4343107

Kinetic aspects of the aggregation of Clostridium perfringens theta-toxin on erythrocyte membranes. A fluorescence energy transfer study.

3 June 2018

1 reference

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Generation of a membrane-bound, oligomerized pre-pore complex is necessary for pore formation by Clostridium septicum alpha toxin.

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423754112

Oligomerization of the channel-forming toxin aerolysin precedes insertion into lipid bilayers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423754112

Controlling pore assembly of staphylococcal gamma-haemolysin by low temperature and by disulphide bond formation in double-cysteine LukF mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423754112

COMPARATIVE KINETICS OF HEMOLYSIS INDUCED BY BACTERIAL AND OTHER HEMOLYSINS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423754112

Key residues for membrane binding, oligomerization, and pore forming activity of staphylococcal alpha-hemolysin identified by cysteine scanning mutagenesis and targeted chemical modification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423754112

The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423754112

Identification of a Membrane-Spanning Domain of the Thiol-Activated Pore-Forming ToxinClostridium perfringensPerfringolysin O: An α-Helical to β-Sheet Transition Identified by Fluorescence Spectroscopy†

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1423754112

The mechanism of pore assembly for a cholesterol-dependent cytolysin: formation of a large prepore complex precedes the insertion of the transmembrane beta-hairpins

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25646411

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An intermediate in the assembly of a pore-forming protein trapped with a genetically-engineered switch

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25646411

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1423754112

1 reference

15 October 2017

0 references

1 reference

15 October 2017

1 reference