Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences (Q30160146)

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English	Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

18 October 2017

Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences (English)

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Europe PubMed Central

PMC publication ID

18 October 2017

Tomasz Skórski

6

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Tomasz Skorski

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Europe PubMed Central

PMC publication ID

18 October 2017

author name string

Shu-Yue Ren

1

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Europe PubMed Central

PMC publication ID

18 October 2017

Elisabeth Bolton

2

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Europe PubMed Central

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18 October 2017

M Golam Mohi

3

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Europe PubMed Central

PMC publication ID

18 October 2017

Andrea Morrione

4

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Europe PubMed Central

PMC publication ID

18 October 2017

Benjamin G Neel

5

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Europe PubMed Central

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18 October 2017

language of work or name

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publication date

1 September 2005

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Europe PubMed Central

PMC publication ID

18 October 2017

Molecular and Cellular Biology

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Europe PubMed Central

PMC publication ID

18 October 2017

25

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Europe PubMed Central

PMC publication ID

18 October 2017

18

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

8001-8008

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors

1 reference

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NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner.

1 reference

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3 June 2018

Molecular mechanisms of transformation by the BCR-ABL oncogene

1 reference

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Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

1 reference

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3 June 2018

Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

1 reference

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Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

1 reference

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Critical role for Gab2 in transformation by BCR/ABL

1 reference

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Tyrosine kinase fusion genes in chronic myeloproliferative diseases.

1 reference

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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Oncogenic tyrosine kinases and the DNA-damage response

1 reference

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3 June 2018

The phosphoinositide 3-kinase pathway

1 reference

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Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

1 reference

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Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis

1 reference

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TEL/platelet-derived growth factor receptor beta activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle

1 reference

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Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway

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Phosphatidyl inositol signaling by BCR/ABL: opportunities for drug development

1 reference

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3 June 2018

Essential role for Gab2 in the allergic response

1 reference

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TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway

1 reference

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3 June 2018

Oncogenic kinase signalling

1 reference

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A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners

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Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis

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Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway

1 reference

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3 June 2018

BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-Kinase/AKT pathway

1 reference

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

1 reference

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3 June 2018

The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf.

1 reference

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3 June 2018

Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt

1 reference

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Signaling pathways activated by oncogenic forms of Abl tyrosine kinase

1 reference

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Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

1 reference

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ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.

1 reference

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The SH3 domain contributes to BCR/ABL-dependent leukemogenesis in vivo: role in adhesion, invasion, and homing

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Protein tyrosine kinases and cancer

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Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

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Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase

1 reference

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Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)

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The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways

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p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines

1 reference

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PI 3-kinase activation in BCR/abl-transformed hematopoietic cells does not require interaction of p85 SH2 domains with p210 BCR/abl

1 reference

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Crystal structure of P13K SH3 domain at 20 angstroms resolution

1 reference

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The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.

1 reference

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A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo

1 reference

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PI 3-kinase: structural and functional analysis of intersubunit interactions

1 reference

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Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth

1 reference

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Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1234343

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Structure of the PI3K SH3 domain and analysis of the SH3 family

1 reference

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Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

1 reference

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Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

1 reference

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Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions

1 reference

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Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells.

1 reference

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Structural basis for the binding of proline-rich peptides to SH3 domains

1 reference

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Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1 reference

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A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction

1 reference

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SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors

1 reference

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Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo

1 reference

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3 June 2018

Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit

1 reference

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3 June 2018

Phosphatidylinositol-3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells

1 reference

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26 November 2018

Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1234343

26 November 2018

Bcr - Abl-mediated resistance to apoptosis is independent of PI 3-kinase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1234343

26 November 2018

Expression of the oncogenic NPM-ALK chimeric protein in human lymphoid T-cells inhibits drug-induced, but not Fas-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1234343

26 November 2018

BCR/ABL regulation of PI-3 kinase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1234343

26 November 2018

Identifiers

10.1128/MCB.25.18.8001-8008.2005

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 October 2017

ResearchGate publication ID

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