The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. (Q30165112)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12411494%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

title

The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells (English)

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14 December 2019

1 reference

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1

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14 December 2019

7

Tomasz Skorski

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14 December 2019

author name string

Steven J Schreiner

2

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14 December 2019

Malgorzata Nieborowska-Skorska

3

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14 December 2019

Artur Slupianek

4

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14 December 2019

Matthew Wilson

5

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14 December 2019

Thomas E Smithgall

6

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14 December 2019

language of work or name

English

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publication date

1 November 2002

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14 December 2019

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14 December 2019

volume

21

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14 December 2019

issue

21

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14 December 2019

page(s)

5766-5774

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Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

14 December 2019

cites work

1 reference

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Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

3 June 2018

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SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo

3 June 2018

1 reference

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Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.

3 June 2018

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BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance

3 June 2018

1 reference

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Src directly tyrosine-phosphorylates STAT5 on its activation site and is involved in erythropoietin-induced signaling pathway

3 June 2018

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Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation

3 June 2018

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Molecular biology of chronic myeloid leukemia

3 June 2018

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Mechanisms of transformation by the BCR/ABL oncogene

3 June 2018

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IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled

3 June 2018

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Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck

3 June 2018

1 reference

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Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

3 June 2018

1 reference

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STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells.

3 June 2018

1 reference

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Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation

3 June 2018

1 reference

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Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF beta-receptor and is not dependent on c-src, fyn, jak1 or jak2 kinases

3 June 2018

1 reference

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STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells

3 June 2018

1 reference

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Signaling pathways activated by oncogenic forms of Abl tyrosine kinase

3 June 2018

1 reference

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Signaling domains of the beta c chain of the GM-CSF/IL-3/IL-5 receptor

3 June 2018

1 reference

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Dominant negative mutants implicate STAT5 in myeloid cell proliferation and neutrophil differentiation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

3 June 2018

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Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Activation of STAT3 by the c-Fes protein-tyrosine kinase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

The SH3 domain contributes to BCR/ABL-dependent leukemogenesis in vivo: role in adhesion, invasion, and homing

3 June 2018

1 reference

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Signal transduction by wild-type and leukemogenic Abl proteins.

3 June 2018

1 reference

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The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr

3 June 2018

1 reference

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The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta

3 June 2018

1 reference

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Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.

3 June 2018

1 reference

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The state of the STATs: recent developments in the study of signal transduction to the nucleus

3 June 2018

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P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

3 June 2018

1 reference

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Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism

3 June 2018

1 reference

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Activation of Src kinases p53/56lyn and p59hck by p210bcr/abl in myeloid cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Regulation of the Src tyrosine kinase and Syp tyrosine phosphatase by their cellular association.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Acute leukaemia in bcr/abl transgenic mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

SH2 and SH3 domains: from structure to function

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=131059

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients

26 November 2018

1 reference

12 December 2020

STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells

1 reference

12 December 2020

Differential effects of prolactin and src/abl kinases on the nuclear translocation of STAT5B and STAT5A

1 reference

12 December 2020

Initiation of deregulated growth of multipotent progenitor cells by bcr-abl in vitro

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/CDF562

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12411494%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12411494%20AND%20SRC:MED&resulttype=core&format=json

14 December 2019

1 reference