Progress towards the treatment of Ebola haemorrhagic fever (Q30230272)

11 June 2017

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title

Progress towards the treatment of Ebola haemorrhagic fever (English)

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11 June 2017

main subject

Ebola hemorrhagic fever

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Orthoebolavirus zairense

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2

Heinz Feldmann

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11 June 2017

1

Ute Ströher

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11 June 2017

language of work or name

English

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publication date

1 December 2006

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Expert Opinion on Investigational Drugs

11 June 2017

published in

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11 June 2017

volume

15

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11 June 2017

issue

12

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11 June 2017

page(s)

1523-1535

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Ebola virus: from discovery to vaccine

11 June 2017

cites work

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Folate receptor alpha and caveolae are not required for Ebola virus glycoprotein-mediated viral infection

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The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.

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21 January 2018

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Ebola and Marburg viruses replicate in monocyte-derived dendritic cells without inducing the production of cytokines and full maturation

21 January 2018

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Ebola and Marburg virus-like particles activate human myeloid dendritic cells

21 January 2018

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Protection from lethal infection is determined by innate immune responses in a mouse model of Ebola virus infection

21 January 2018

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The Ebola virus VP35 protein functions as a type I IFN antagonist.

21 January 2018

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Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection

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21 January 2018

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Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients

21 January 2018

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Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells

21 January 2018

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21 January 2018

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Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys

21 January 2018

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Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event

21 January 2018

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Pathogenesis of experimental Ebola virus infection in guinea pigs

21 January 2018

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A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The highly specific carbohydrate-binding protein cyanovirin-N: structure, anti-HIV/Ebola activity and possibilities for therapy

21 January 2018

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Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus

21 January 2018

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Functional importance of the coiled-coil of the Ebola virus glycoprotein

21 January 2018

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Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones

21 January 2018

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Furin at the cutting edge: from protein traffic to embryogenesis and disease

21 January 2018

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Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture

21 January 2018

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Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection

21 January 2018

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21 January 2018

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21 January 2018

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Experimental study on the possibility of treatment of some hemorrhagic fevers

21 January 2018

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21 January 2018

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Adenosine analogs inhibit the guanine-7-methylation of mRNA cap structures

21 January 2018

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Antiviral drug therapy of filovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit Ebola virus in vitro and in a lethal mouse model

21 January 2018

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Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor

21 January 2018

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3-deazaneplanocin A induces massively increased interferon-alpha production in Ebola virus-infected mice

21 January 2018

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Intracellular phosphorylation of carbocyclic 3-deazaadenosine, an anti-Ebola virus agent

21 January 2018

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Experimental therapy of filovirus infections

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Inhibition of Marburg virus protein expression and viral release by RNA interference

21 January 2018

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Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference

21 January 2018

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Resistance of morpholino phosphorodiamidate oligomers to enzymatic degradation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice

21 January 2018

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Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers.

21 January 2018

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Oligomerization of Ebola virus VP30 is essential for viral transcription and can be inhibited by a synthetic peptide

21 January 2018

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Late budding domains and host proteins in enveloped virus release

21 January 2018

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Ebola virus VP40 late domains are not essential for viral replication in cell culture

21 January 2018

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Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling

21 January 2018

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A C-terminal basic amino acid motif of Zaire ebolavirus VP35 is essential for type I interferon antagonism and displays high identity with the RNA-binding domain of another interferon antagonist, the NS1 protein of influenza A virus

21 January 2018

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21 January 2018

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Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates

21 January 2018

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21 January 2018

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Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses

21 January 2018

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Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses

21 January 2018

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Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment

21 January 2018

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RNA polymerase I-driven minigenome system for Ebola viruses

21 January 2018

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Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening

21 January 2018

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Recovery of infectious Ebola virus from complementary DNA: RNA editing of the GP gene and viral cytotoxicity

21 January 2018

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10.1517/13543784.15.12.1523

21 January 2018

Identifiers

DOI

1 reference

11 June 2017

1 reference