Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes. (Q30333153)

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English	Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes.	scientific article

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scholarly article

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Europe PubMed Central

18 June 2017

Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes. (English)

1 reference

Europe PubMed Central

18 June 2017

author name string

Holger Gohlke

1

1 reference

Europe PubMed Central

18 June 2017

Christina Kiel

2

1 reference

Europe PubMed Central

18 June 2017

David A Case

3

1 reference

Europe PubMed Central

18 June 2017

language of work or name

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publication date

1 July 2003

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Europe PubMed Central

18 June 2017

Journal of Molecular Biology

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Europe PubMed Central

18 June 2017

330

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Europe PubMed Central

18 June 2017

4

1 reference

Europe PubMed Central

18 June 2017

891-913

1 reference

Europe PubMed Central

18 June 2017

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Mini-review: computational structure-based design of inhibitors that target protein surfaces

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Principles of protein-protein interactions

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Interactions of protein antigens with antibodies

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Stability of macromolecular complexes

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Conservation of polar residues as hot spots at protein interfaces

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Rational design of faster associating and tighter binding protein complexes.

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Unraveling hot spots in binding interfaces: progress and challenges

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Biomolecular simulations: recent developments in force fields, simulations of enzyme catalysis, protein-ligand, protein-protein, and protein-nucleic acid noncovalent interactions

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The GTPase superfamily: conserved structure and molecular mechanism

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How Ras-related proteins talk to their effectors

1 reference

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Regulation of Ras-mediated signalling: more than one way to skin a cat.

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

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Increasing complexity of Ras signaling.

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1 reference

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Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surface

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Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

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Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

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Structural and biochemical analysis of Ras-effector signaling via RalGDS

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Structural basis for the interaction of Ras with RalGDS

1 reference

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

1 reference

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Ras/Rap effector specificity determined by charge reversal

1 reference

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Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex†

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Conformational transitions in p21ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP.

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Interactions between Ras proteins and their effectors

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Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins

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Regulation of the Raf kinase by phosphorylation

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Thermodynamics of Ras/effector and Cdc42/effector interactions probed by isothermal titration calorimetry

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Conformation of the Ras-binding domain of Raf studied by molecular dynamics and free energy simulations.

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Free energy decomposition of protein-protein interactions.

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10.1016/S0022-2836(03)00610-7

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Europe PubMed Central

18 June 2017

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Europe PubMed Central

18 June 2017

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