Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase. (Q30366916)

13 October 2017

Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase. (English)

1 reference

13 October 2017

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5

A R Brash

1 reference

13 October 2017

David B Neau

1

1 reference

13 October 2017

Gunes Bender

2

1 reference

13 October 2017

William E Boeglin

3

1 reference

13 October 2017

Sue G Bartlett

4

1 reference

13 October 2017

Marcia E Newcomer

6

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13 October 2017

language of work or name

English

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publication date

17 September 2014

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Journal of Biological Chemistry

13 October 2017

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13 October 2017

289

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13 October 2017

46

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13 October 2017

31905-31913

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Structure-Based Mutational Studies of Substrate Inhibition of Betaine Aldehyde Dehydrogenase BetB from Staphylococcus aureus

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

The structure of human 15-lipoxygenase-2 with a substrate mimic

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Site-directed mutagenesis of catalytic residues in N(5)-carboxyaminoimidazole ribonucleotide synthetase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

How good are my data and what is the resolution?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Linking Crystallographic Model and Data Quality

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Structure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca2+ Regulation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Applications of stereospecifically-labeled Fatty acids in oxygenase and desaturase biochemistry

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

The structure of human 5-lipoxygenase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Molecular enzymology of lipoxygenases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

PHENIX: a comprehensive Python-based system for macromolecular structure solution

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Integration, scaling, space-group assignment and post-refinement

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Lipoxygenases - Structure and reaction mechanism.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Removal of substrate inhibition and increase in maximal velocity in the short chain dehydrogenase/reductase salutaridine reductase involved in morphine biosynthesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

The 1.85 Å Structure of an 8 R -Lipoxygenase Suggests a General Model for Lipoxygenase Product Specificity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Improving protein crystal quality by selective removal of a Ca(2+)-dependent membrane-insertion loop

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Conformational flexibility in mammalian 15S-lipoxygenase: Reinterpretation of the crystallographic data

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Control of oxygenation in lipoxygenase and cyclooxygenase catalysis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

How do enzymes activate oxygen without inactivating themselves?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Scaling and assessment of data quality

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Coot: model-building tools for molecular graphics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Enantiomeric separation of hydroxy eicosanoids by chiral column chromatography: effect of the alcohol modifier.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Crystal structure of soybean lipoxygenase L-1 at 1.4 A resolution

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

The three-dimensional structure of an arachidonic acid 15-lipoxygenase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Excess-substrate inhibition in enzymology and high-dose inhibition in pharmacology: a reinterpretation [corrected]

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Mammalian lipoxygenases: molecular structures and functions

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4231669

Insights from the X-ray crystal structure of coral 8R-lipoxygenase: calcium activation via a C2-like domain and a structural basis of product chirality

3 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.599662

Is substrate inhibition a consequence of allostery in aspartate transcarbamylase?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.599662

Substrate inhibition of Lactococcus lactis cytidine 5'-triphosphate synthase by ammonium chloride is enhanced by salt-dependent tetramer dissociation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.599662

The Determination of Enzyme Dissociation Constants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.599662

An unusual isotope effect on substrate inhibition in the oxidation of arachidonic acid by lipoxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.599662

Steric control of oxygenation regiochemistry in soybean lipoxygenase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.599662

Shape and specificity in mammalian 15-lipoxygenase active site. The functional interplay of sequence determinants for the reaction specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M114.599662

Purification and catalytic activities of the two domains of the allene oxide synthase-lipoxygenase fusion protein of the coral Plexaura homomalla

21 January 2018

1 reference

12 December 2020

On the Specificity of the Oxygenation of Unsaturated Fatty Acids Catalyzed by Soybean Lipoxidase

1 reference

12 December 2020

Stereospecificity of the hydrogen abstraction at carbon atom n-8 in the oxygenation of linoleic acid by lipoxygenases from corn germs and soya beans

1 reference

12 December 2020

On singular or dual positional specificity of lipoxygenases. The number of chiral products varies with alignment of methylene groups at the active site of the enzyme

1 reference

12 December 2020

Excess substrate inhibition of soybean lipoxygenase-1 is mainly oxygen-dependent

1 reference

12 December 2020

Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M114.599662

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

25231982

1 reference