A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis. (Q30371769)

21 June 2017

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title

A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis. (English)

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21 June 2017

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Melanie Stegman

4

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Luiz Pedro S de Carvalho

object named as

Luiz Pedro Sorio de Carvalho

5

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Carl F. Nathan

1

object named as

Carl Nathan

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21 June 2017

Ben Gold

2

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21 June 2017

Gang Lin

3

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21 June 2017

Omar Vandal

6

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21 June 2017

Aditya Venugopal

7

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21 June 2017

Ruslana Bryk

8

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21 June 2017

1 August 2008

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21 June 2017

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21 June 2017

88 Suppl 1

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21 June 2017

S25-33

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Mycobacterium tuberculosis: here today, and here tomorrow

21 June 2017

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7 January 2021

The growing burden of tuberculosis: global trends and interactions with the HIV epidemic

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Global epidemiology of tuberculosis

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Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa

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XDR Tuberculosis — Implications for Global Public Health

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Convergence of the tuberculosis and diabetes epidemics: renewal of old acquaintances

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Diabetes and tuberculosis: the impact of the diabetes epidemic on tuberculosis incidence

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Anti-infective antibodies: finding the path forward

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Antibiotics at the crossroads

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7 January 2021

New approaches to filling the gap in tuberculosis drug discovery

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STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : I. PREPARATION OF THE AGENT. ITS ACTIVITY IN VITRO.

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THE PROTECTIVE ACTION OF A SPECIFIC ENZYME AGAINST TYPE III PNEUMOCOCCUS INFECTION IN MICE.

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7 January 2021

Tuberculosis - metabolism and respiration in the absence of growth

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7 January 2021

Replication dynamics of Mycobacterium tuberculosis in chronically infected mice

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7 January 2021

Expression levels of Mycobacterium tuberculosis antigen-encoding genes versus production levels of antigen-specific T cells during stationary level lung infection in mice.

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7 January 2021

Non-inherited antibiotic resistance.

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Tuberculosis chemotherapy: the influence of bacillary stress and damage response pathways on drug efficacy

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Microbial persistence. I. The capacity of tubercle bacilli to survive sterilization in mouse tissues

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Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

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Oxygen status of lung granulomas in Mycobacterium tuberculosis-infected mice.

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7 January 2021

Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

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7 January 2021

BCG-osis and tuberculosis in a child with chronic granulomatous disease

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Attenuation of and protection induced by a leucine auxotroph of Mycobacterium tuberculosis

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7 January 2021

A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis.

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7 January 2021

Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence

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7 January 2021

Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program

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7 January 2021

Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients

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7 January 2021

Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment

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7 January 2021

Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence

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7 January 2021

Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration

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Inducible nitric oxide synthase in the tuberculous human lung

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7 January 2021

Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates

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7 January 2021

Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo.

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7 January 2021

Is adipose tissue a place for Mycobacterium tuberculosis persistence?

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7 January 2021

M. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid Cells

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Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages

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Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy

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The role of macrophage cell death in tuberculosis

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Selective killing of nonreplicating mycobacteria

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7 January 2021

The future challenges facing the development of new antimicrobial drugs.

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7 January 2021

Where will new antibiotics come from?

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7 January 2021

Genes required for mycobacterial growth defined by high density mutagenesis

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Genetic requirements for mycobacterial survival during infection

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A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

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Regulation of Mycobacterium tuberculosis cell envelope composition and virulence by intramembrane proteolysis

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The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide

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7 January 2021

Role for nucleotide excision repair in virulence of Mycobacterium tuberculosis

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7 January 2021

Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

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7 January 2021

Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy

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Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome

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7 January 2021

Oxidized proteins: intracellular distribution and recognition by the proteasome

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7 January 2021

Accumulation of misfolded protein through nitrosative stress linked to neurodegenerative disorders

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7 January 2021

Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions

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7 January 2021

Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions

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7 January 2021

Protein synthesis is shutdown in dormant Mycobacterium tuberculosis and is reversed by oxygen or heat shock

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7 January 2021

Mycobacterium tuberculosis prcBA genes encode a gated proteasome with broad oligopeptide specificity

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7 January 2021

Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate

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7 January 2021

In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice

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7 January 2021

The magic bullets and tuberculosis drug targets.

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7 January 2021

A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis

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7 January 2021

Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein

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7 January 2021

Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes

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7 January 2021

Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis

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7 January 2021

Mycobacterium tuberculosis lipoamide dehydrogenase is encoded by Rv0462 and not by the lpdA or lpdB genes

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7 January 2021

Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation

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Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis

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Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase

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Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase

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Molecular cloning of the Corynebacterium glutamicum ('Brevibacterium lactofermentum' AJ12036) odhA gene encoding a novel type of 2-oxoglutarate dehydrogenase.

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The growing impact of click chemistry on drug discovery

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Natural product growth inhibitors of Mycobacterium tuberculosis.

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Aligning pharmaceutical innovation with medical need

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7 January 2021

10.1016/S1472-9792(08)70034-9

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DOI

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21 June 2017

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