Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. (Q30385239)

15 September 2017

Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. (English)

1 reference

15 September 2017

John S Tokarski

1

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15 September 2017

Adriana Zupa-Fernandez

2

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15 September 2017

Jeffrey A Tredup

3

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15 September 2017

Kristen Pike

4

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15 September 2017

ChiehYing Chang

5

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15 September 2017

Dianlin Xie

6

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15 September 2017

Lihong Cheng

7

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15 September 2017

Donna Pedicord

8

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15 September 2017

Jodi Muckelbauer

9

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15 September 2017

Stephen R Johnson

10

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15 September 2017

Sophie Wu

11

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15 September 2017

Suzanne C Edavettal

12

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15 September 2017

Yang Hong

13

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15 September 2017

Mark R Witmer

14

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15 September 2017

Lisa L Elkin

15

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15 September 2017

Yuval Blat

16

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15 September 2017

William J Pitts

17

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15 September 2017

David S Weinstein

18

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15 September 2017

James R Burke

19

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15 September 2017

language of work or name

English

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publication date

11 March 2015

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Journal of Biological Chemistry

15 September 2017

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15 September 2017

290

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15 September 2017

17

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15 September 2017

11061-11074

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Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

15 September 2017

1 reference

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Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases

20 June 2018

1 reference

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Activating Janus kinase pseudokinase domain mutations in myeloproliferative and other blood cancers

20 June 2018

1 reference

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Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors

20 June 2018

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Selective JAK1 inhibitor and selective Tyk2 inhibitor patents

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20 June 2018

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Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2.

20 June 2018

1 reference

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REFMAC5 for the refinement of macromolecular crystal structures

20 June 2018

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Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility

20 June 2018

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20 June 2018

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Pseudokinases-remnants of evolution or key allosteric regulators?

20 June 2018

1 reference

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Features and development of Coot

20 June 2018

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The JAK2V617 mutation induces constitutive activation and agonist hypersensitivity in basophils from patients with polycythemia vera

20 June 2018

1 reference

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Phasercrystallographic software

20 June 2018

1 reference

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Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

20 June 2018

1 reference

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Why did IL-12/IL-23 antibody therapy fail in multiple sclerosis?

20 June 2018

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20 June 2018

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Differential regulation of STAT family members by glycogen synthase kinase-3

20 June 2018

1 reference

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The JAK-STAT signaling pathway: input and output integration

20 June 2018

1 reference

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The V617F JAK2 mutation and the myeloproliferative disorders

20 June 2018

1 reference

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JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.

20 June 2018

1 reference

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Thermodynamic stability of carbonic anhydrase: measurements of binding affinity and stoichiometry using ThermoFluor.

20 June 2018

1 reference

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Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain

20 June 2018

1 reference

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The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

20 June 2018

1 reference

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Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase

20 June 2018

1 reference

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21 January 2018

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Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence

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Identifiers

DOI

10.1074/JBC.M114.619502

1 reference

15 September 2017

1 reference

15 September 2017

PubMed publication ID

25762719

1 reference