Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS (Q30391992)

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21 March 2020

title

Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS (English)

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21 March 2020

4

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21 March 2020

author name string

Yunxing Li

1

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21 March 2020

Jon W Erickson

2

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21 March 2020

Clint A Stalnecker

3

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21 March 2020

Qingqiu Huang

5

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21 March 2020

Richard A Cerione

6

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21 March 2020

Sekar Ramachandran

7

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21 March 2020

language of work or name

English

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publication date

19 August 2016

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Journal of Biological Chemistry

21 March 2020

published in

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21 March 2020

volume

291

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21 March 2020

issue

40

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21 March 2020

page(s)

20900-20910

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The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy.

21 March 2020

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Small angle X-ray scattering studies of mitochondrial glutaminase C reveal extended flexible regions, and link oligomeric state with enzyme activity

20 June 2018

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Therapeutic strategies impacting cancer cell glutamine metabolism

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Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor

20 June 2018

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

20 June 2018

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Cancer cell metabolism: one hallmark, many faces.

20 June 2018

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Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth

20 June 2018

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Mechanistic insights into the regulation of metabolic enzymes by acetylation

20 June 2018

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Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

20 June 2018

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Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

20 June 2018

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Full-length human glutaminase in complex with an allosteric inhibitor

20 June 2018

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Glutaminase: a hot spot for regulation of cancer cell metabolism?

20 June 2018

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The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

20 June 2018

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Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

20 June 2018

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Glutamine addiction: a new therapeutic target in cancer

20 June 2018

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

20 June 2018

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

20 June 2018

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

20 June 2018

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

20 June 2018

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

20 June 2018

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Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES)

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Solution of protein crystallographic structures by high-pressure cryocooling and noble-gas phasing

20 June 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27542409

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M116.720268

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21 March 2020

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21 March 2020

PubMed publication ID

27542409

1 reference