Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins. (Q30397851)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24870016%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins (English)

1 reference

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high-throughput screening

19 March 2020

main subject

0 references

1 reference

15

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19 March 2020

Beeraiah Baire

17

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19 March 2020

Gunda I. Georg

21

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19 March 2020

Michael A Walters

22

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19 March 2020

11

Barry O'Keefe

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19 March 2020

author name string

Christian A Hassig

1

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19 March 2020

Fu-Yue Zeng

2

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19 March 2020

Paul Kung

3

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19 March 2020

Mehrak Kiankarimi

4

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19 March 2020

Sylvia Kim

5

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19 March 2020

Paul W Diaz

6

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19 March 2020

Dayong Zhai

7

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19 March 2020

Kate Welsh

8

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19 March 2020

Shana Morshedian

9

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19 March 2020

Ying Su

10

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19 March 2020

David J Newman

12

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19 March 2020

Yudi Rusman

13

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19 March 2020

Harneet Kaur

14

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19 March 2020

Susan G Brown

16

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19 March 2020

Andrew R Michel

18

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19 March 2020

Thomas R Hoye

19

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19 March 2020

Subhashree Francis

20

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19 March 2020

Daniela B Divlianska

23

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19 March 2020

Gregory P Roth

24

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19 March 2020

Amy E Wright

25

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19 March 2020

John C Reed

26

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19 March 2020

publication date

27 May 2014

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Journal of Biomolecular Screening

19 March 2020

published in

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volume

19

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issue

8

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page(s)

1201-1211

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Matching the power of high throughput screening to the chemical diversity of natural products

19 March 2020

cites work

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ABT-199: taking dead aim at BCL-2

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ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

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Alternaria toxins: Altertoxin II is a much stronger mutagen and DNA strand breaking mycotoxin than alternariol and its methyl ether in cultured mammalian cells

20 June 2018

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20 June 2018

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High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1.

20 June 2018

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A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy

20 June 2018

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Still embedded together binding to membranes regulates Bcl-2 protein interactions.

20 June 2018

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Mitochondrial signaling in cell death via the Bcl-2 family

20 June 2018

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Mimicking the BH3 domain to kill cancer cells

20 June 2018

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Drug discovery and natural products: end of an era or an endless frontier?

20 June 2018

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Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1.

20 June 2018

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The Bcl-2 apoptotic switch in cancer development and therapy

20 June 2018

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Development of Novel Assays for Proteolytic Enzymes Using Rhodamine-Based Fluorogenic Substrates

20 June 2018

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Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

20 June 2018

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Characterization of the anti-apoptotic mechanism of Bcl-B

20 June 2018

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Inhibition of human telomerase activity by alterperylenol.

20 June 2018

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Mutagenicity of the Alternaria metabolites altertoxins I, II, and III.

20 June 2018

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Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

20 June 2018

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Comparative genomics: the evolutionary history of the Bcl-2 family.

20 June 2018

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Use of red-shifted dyes in a fluorescence polarization AKT kinase assay for detection of biological activity in natural product extracts

21 January 2018

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Characterization of a genotoxic impact compound in Alternaria alternata infested rice as Altertoxin II.

21 January 2018

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Phylogenomics of life-or-death switches in multicellular animals: Bcl-2, BH3-Only, and BNip families of apoptotic regulators

21 January 2018

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12 December 2020

Non-stoichiometric inhibition in biochemical high-throughput screening

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12 December 2020

Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay

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Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins

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12 December 2020

Identifiers

DOI

10.1177/1087057114536227

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24870016%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24870016%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

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