Still embedded together binding to membranes regulates Bcl-2 protein interactions. (Q37773789)

22 August 2017

1 reference

title

Still embedded together binding to membranes regulates Bcl-2 protein interactions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6459407&resulttype=core&format=json

13 May 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6459407&resulttype=core&format=json

13 May 2020

David William Andrews

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6459407&resulttype=core&format=json

13 May 2020

author name string

J Lin

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6459407&resulttype=core&format=json

13 May 2020

language of work or name

English

0 references

publication date

19 July 2010

1 reference

22 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6459407&resulttype=core&format=json

13 May 2020

volume

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6459407&resulttype=core&format=json

13 May 2020

issue

38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6459407&resulttype=core&format=json

13 May 2020

page(s)

5221-5230

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6459407&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/onc.2010.283

13 May 2020

exact match

0 references

cites work

Modeling a snap-action, variable-delay switch controlling extrinsic cell death

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bcl-XL inhibits membrane permeabilization by competing with Bax.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bid: a Bax-like BH3 protein.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Mimicking the BH3 domain to kill cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Apoptosis and cancer: the genesis of a research field

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

31 March 2020

Bax activation by Bim?

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

BAD: undertaker by night, candyman by day.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Heat-Induced Dimerization of BCL-xLthrough α-Helix Swapping†

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

BAX activation is initiated at a novel interaction site

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Apoptosis: Stabbed in the BAX.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

31 March 2020

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Reversible membrane interaction of BAD requires two C-terminal lipid binding domains in conjunction with 14-3-3 protein binding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Nonionic detergents induce dimerization among members of the Bcl-2 family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Detergent-activated BAX protein is a monomer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

BH3-only proteins in apoptosis and beyond: an overview

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bim and Bmf in tissue homeostasis and malignant disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Noxa: at the tip of the balance between life and death.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Mitochondrial outer membrane proteins assist Bid in Bax-mediated lipidic pore formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Mitochondrial dynamics and apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

BIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

The BCL-2 protein family: opposing activities that mediate cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

PUMA, a potent killer with or without p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bax forms an oligomer via separate, yet interdependent, surfaces

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.283

Bcl-2 changes conformation to inhibit Bax oligomerization

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20639903

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20639903

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2010.283

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6459407&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6459407&resulttype=core&format=json

13 May 2020

1 reference