Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit (Q30407440)

10 August 2017

Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit (English)

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10 August 2017

Chihiro Nozaki

1

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10 August 2017

Angela Maria Vergnano

2

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10 August 2017

Dominique Filliol

3

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10 August 2017

Abdel-Mouttalib Ouagazzal

4

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10 August 2017

Anne Le Goff

5

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10 August 2017

Stéphanie Carvalho

6

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10 August 2017

David Reiss

7

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10 August 2017

Claire Gaveriaux-Ruff

8

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10 August 2017

Jacques Neyton

9

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10 August 2017

Pierre Paoletti

10

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10 August 2017

Brigitte L Kieffer

11

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10 August 2017

language of work or name

English

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publication date

3 July 2011

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10 August 2017

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10 August 2017

14

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10 August 2017

8

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10 August 2017

1017-1022

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describes a project that uses

10 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4494785/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Triheteromeric NR1/NR2A/NR2B receptors constitute the major N-methyl-D-aspartate receptor population in adult hippocampal synapses

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Glutamate receptor ion channels: structure, regulation, and function

20 June 2018

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Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain

20 June 2018

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Cellular and Molecular Mechanisms of Pain

20 June 2018

1 reference

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Zinc in the physiology and pathology of the CNS.

20 June 2018

1 reference

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Central sensitization: a generator of pain hypersensitivity by central neural plasticity

20 June 2018

1 reference

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Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential

20 June 2018

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Mechanism of differential control of NMDA receptor activity by NR2 subunits

20 June 2018

1 reference

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Zinc activates damage-sensing TRPA1 ion channels

20 June 2018

1 reference

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COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice

20 June 2018

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Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo

20 June 2018

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Zinc at glutamatergic synapses.

20 June 2018

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NMDA di-heteromeric receptor populations and associated proteins in rat hippocampus

20 June 2018

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Understanding LTP in pain pathways

20 June 2018

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Zinc deficiency: a special challenge

20 June 2018

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Peripheral neuropathy: pathogenic mechanisms and alternative therapies

20 June 2018

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Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission

20 June 2018

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Synaptically released zinc gates long-term potentiation in fear conditioning pathways.

20 June 2018

1 reference

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Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo

20 June 2018

1 reference

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The neurobiology of zinc in health and disease

20 June 2018

1 reference

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Zn2+ ions: modulators of excitatory and inhibitory synaptic activity.

20 June 2018

1 reference

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Spinal p38 MAP kinase is necessary for NMDA-induced spinal PGE(2) release and thermal hyperalgesia

20 June 2018

1 reference

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Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes

20 June 2018

1 reference

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Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits.

20 June 2018

1 reference

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Animal models of nociception.

20 June 2018

1 reference

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Inhibitory zinc-enriched terminals in mouse spinal cord

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494785

Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494785

Neuronal plasticity: increasing the gain in pain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494785

Importance of zinc in the central nervous system: the zinc-containing neuron

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494785

The actions of synaptically released zinc at hippocampal mossy fiber synapses.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494785

The spinal biology in humans and animals of pain states generated by persistent small afferent input

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494785

Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494785

High-affinity zinc inhibition of NMDA NR1-NR2A receptors.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4494785

The effects of Zn2+ on long-term potentiation of C fiber-evoked potentials in the rat spinal dorsal horn

20 June 2018

1 reference

Depletion of vesicular zinc in dorsal horn of spinal cord causes increased neuropathic pain in mice

21 January 2018

1 reference

Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit.

21 January 2018

1 reference

Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors

21 January 2018

1 reference

The relationship between serum trace element levels and clinical parameters in patients with fibromyalgia.

21 January 2018

1 reference

Clinical study of tongue pain: Serum zinc, vitamin B12, folic acid, and copper concentrations, and systemic disease

21 January 2018

1 reference

Modulation of triheteromeric NMDA receptors by N-terminal domain ligands

21 January 2018

1 reference

Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn.

21 January 2018

1 reference

Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia

21 January 2018

1 reference

Zinc alleviates thermal hyperalgesia due to partial nerve injury

21 January 2018

1 reference

12 December 2020

Localization of N-methyl-D-aspartate NR2B subunits on primary sensory neurons that give rise to small-caliber sciatic nerve fibers in rats

1 reference

12 December 2020

Manipulations of zinc in the spinal cord, by intrathecal injection of zinc chloride, disodium-calcium-EDTA, or dipicolinic acid, alter nociceptive activity in mice

1 reference

12 December 2020

Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence

1 reference

12 December 2020

The capsaicin test in mice for evaluating tachykinin antagonists in the spinal cord

1 reference

12 December 2020

The distribution of zinc selenite and expression of metallothionein-III mRNA in the spinal cord and dorsal root ganglia of the rat suggest a role for zinc in sensory transmission

1 reference

12 December 2020

Zinc reduces the hyperalgesia and upregulation of NGF and IL-1 beta produced by peripheral inflammation in the rat

1 reference

12 December 2020

Identifiers

DOI

10.1038/NN.2844

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10 August 2017

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10 August 2017

PubMed publication ID

21725314

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