Zinc activates damage-sensing TRPA1 ion channels (Q39885917)

15 September 2017

Zinc activates damage-sensing TRPA1 ion channels (English)

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15 September 2017

5

Ardem Patapoutian

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15 September 2017

2

Michael Bandell

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15 September 2017

3

Matt J Petrus

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15 September 2017

Hongzhen Hu

1

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PMCID

2677965

15 September 2017

Michael X Zhu

series ordinal

4

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15 September 2017

8 February 2009

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15 September 2017

Nature Chemical Biology

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15 September 2017

5

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15 September 2017

3

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15 September 2017

183-190

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https://scigraph.springernature.com/pub.10.1038/nchembio.146

15 September 2017

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cites work

Transient receptor potential channels: targeting pain at the source

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An ion channel essential for sensing chemical damage.

22 September 2017

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From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs

22 September 2017

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TRPA1 mediates formalin-induced pain

22 September 2017

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Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels

22 September 2017

1 reference

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Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Zinc is a novel intracellular second messenger

22 September 2017

1 reference

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TRPM8 is required for cold sensation in mice

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

The zinc/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling

22 September 2017

1 reference

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Zn2+-dependent redox switch in the intracellular T1-T1 interface of a Kv channel

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

TRP channel activation by reversible covalent modification

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Trp ion channels and temperature sensation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability.

22 September 2017

1 reference

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TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

The neurobiology of zinc in health and disease

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

A zinc-sensing receptor triggers the release of intracellular Ca2+ and regulates ion transport

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Inhibitory zinc-enriched terminals in mouse spinal cord

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Zinc homeostasis in humans

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Excursions of intake above ADI: case study on cadmium

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Early pulmonary cytokine responses to zinc oxide fume inhalation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

The capsaicin receptor: a heat-activated ion channel in the pain pathway

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Cytokines in metal fume fever

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

The biochemical basis of zinc physiology

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Cadmium chemical pneumonitis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Detection and imaging of zinc secretion from pancreatic beta-cells using a new fluorescent zinc indicator

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Bimodal action of menthol on the transient receptor potential channel TRPA1.

15 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Depletion of vesicular zinc in dorsal horn of spinal cord causes increased neuropathic pain in mice.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

More than cool: promiscuous relationships of menthol and other sensory compounds.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2677965

Effects of interleukin-1 beta, interleukin-6, and tumor necrosis factor on sensitivity of dorsal root ganglion and peripheral receptive fields in rats

20 August 2018

1 reference

12 December 2020

Analysis of the structural consensus of the zinc coordination centers of metalloprotein structures

1 reference

12 December 2020

Detection of secretion from single pancreatic beta-cells using extracellular fluorogenic reactions and confocal fluorescence microscopy

1 reference

12 December 2020

Zinc is the toxic factor in the lung response to an atmospheric particulate sample

1 reference

12 December 2020

Measuring zinc in living cells. A new generation of sensitive and selective fluorescent probes

1 reference

12 December 2020

Zinc reduces the hyperalgesia and upregulation of NGF and IL-1 beta produced by peripheral inflammation in the rat

1 reference

12 December 2020

Manipulations of zinc in the spinal cord, by intrathecal injection of zinc chloride, disodium-calcium-EDTA, or dipicolinic acid, alter nociceptive activity in mice

1 reference

12 December 2020

The distribution of zinc selenite and expression of metallothionein-III mRNA in the spinal cord and dorsal root ganglia of the rat suggest a role for zinc in sensory transmission

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.146

1 reference

PMCID

2677965

Dimensions Publication ID

15 September 2017

0 references

1 reference

15 September 2017

1 reference

PMCID

2677965