Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes (Q30415151)

20 August 2017

Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes (English)

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20 August 2017

12

Bert Vogelstein

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Victor Velculescu

object named as

Victor E Velculescu

8

0 references

Kenneth W. Kinzler

7

object named as

Kenneth W Kinzler

1 reference

20 August 2017

10

Sanford D Markowitz

1 reference

20 August 2017

9

Tobias Sjöblom

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20 August 2017

11

Steven M Powell

1 reference

20 August 2017

Melinda D Willard

1

1 reference

20 August 2017

Mary E Lajiness

2

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20 August 2017

Isabella H Wulur

3

1 reference

20 August 2017

Bo Feng

4

1 reference

20 August 2017

Michelle L Swearingen

5

1 reference

20 August 2017

Mark T Uhlik

6

1 reference

20 August 2017

Thomas D Barber

13

1 reference

20 August 2017

19 April 2012

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Molecular Cancer Research

20 August 2017

1 reference

20 August 2017

10

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20 August 2017

6

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20 August 2017

739-749

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describes a project that uses

20 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3904773/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types

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Diverse somatic mutation patterns and pathway alterations in human cancers

20 June 2018

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Gastrin stimulates the VEGF-A promotor in a human colon cancer cell line

20 June 2018

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Z-360, a novel cholecystokinin-2/gastrin receptor antagonist, inhibits gemcitabine-induced expression of the vascular endothelial growth factor gene in human pancreatic cancer cells

20 June 2018

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The year in G protein-coupled receptor research

20 June 2018

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A phase Ib/IIa trial to evaluate the CCK2 receptor antagonist Z-360 in combination with gemcitabine in patients with advanced pancreatic cancer

20 June 2018

1 reference

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CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells

20 June 2018

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CCK(2) receptor splice variant with intron 4 retention in human gastrointestinal and lung tumours

20 June 2018

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Evidence for a direct and functional interaction between the regulators of G protein signaling-2 and phosphorylated C terminus of cholecystokinin-2 receptor.

20 June 2018

1 reference

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Lamellipodia and filopodia in metastasis and invasion

20 June 2018

1 reference

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Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

20 June 2018

1 reference

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Effect of Z-360, a novel orally active CCK-2/gastrin receptor antagonist on tumor growth in human pancreatic adenocarcinoma cell lines in vivo and mode of action determinations in vitro

20 June 2018

1 reference

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Alternative splicing in cancer: noise, functional, or systematic?

20 June 2018

1 reference

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G-protein-coupled receptors and cancer.

20 June 2018

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An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway

20 June 2018

1 reference

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Constitutively active CCK2 receptor splice variant increases Src-dependent HIF-1 alpha expression and tumor growth

20 June 2018

1 reference

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Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas

20 June 2018

1 reference

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Cholecystokinin and gastrin receptors

20 June 2018

1 reference

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Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials.

20 June 2018

1 reference

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Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis

20 June 2018

1 reference

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SRC regulates constitutive internalization and rapid resensitization of a cholecystokinin 2 receptor splice variant

20 June 2018

1 reference

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Valine-286 residue in the third intracellular loop of the cholecystokinin 2 receptor exerts a pivotal role in cholecystokinin 2 receptor mediated intracellular signal transduction in human colon cancer cells

20 June 2018

1 reference

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Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production

20 June 2018

1 reference

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Agonist-independent activation of Src tyrosine kinase by a cholecystokinin-2 (CCK2) receptor splice variant

20 June 2018

1 reference

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IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis

20 June 2018

1 reference

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Matrix metalloproteinases, angiogenesis, and cancer: commentary re: A. C. Lockhart et al., Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor. Clin. Cancer Res., 9: 00-00, 2003.

20 June 2018

1 reference

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Characterization of the CCK-C (cancer) receptor in human pancreatic cancer.

20 June 2018

1 reference

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A misspliced form of the cholecystokinin-B/gastrin receptor in pancreatic carcinoma: role of reduced sellular U2AF35 and a suboptimal 3'-splicing site leading to retention of the fourth intron

20 June 2018

1 reference

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Gastrin induces CXC chemokine expression in gastric epithelial cells through activation of NF-kappaB.

20 June 2018

1 reference

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Angiogenesis and G-protein-coupled receptors: signals that bridge the gap.

20 June 2018

1 reference

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Human colorectal cancers express a constitutively active cholecystokinin-B/gastrin receptor that stimulates cell growth

20 June 2018

1 reference

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Clinical applications of angiogenic growth factors and their inhibitors

20 June 2018

1 reference

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Glycine-extended gastrin regulates HEK cell growth

20 June 2018

1 reference

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Single amino acid substitution of serine82 to asparagine in first intracellular loop of human cholecystokinin (CCK)-B receptor confers full cyclic AMP responses to CCK and gastrin.

20 June 2018

1 reference

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Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904773

Antiproliferative effect of a novel cholecystokinin-B/gastrin receptor antagonist, YM022.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904773

Cholecystokinin-B/gastrin receptor signaling pathway involves tyrosine phosphorylations of p125FAK and p42MAP.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904773

Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904773

Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904773

Tumor angiogenesis: therapeutic implications

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904773

Differential pp60c-src activity in well and poorly differentiated human colon carcinomas and cell lines

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904773

The CCK-2/gastrin splice variant receptor retaining intron 4 transactivates the COX-2 promoter in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904773

Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904773

Stimulation of gastrin-CCKB receptor promotes migration of gastric AGS cells via multiple paracrine pathways

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904773

CCK-B/gastrin receptors in human colorectal cancer

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904773

Src activation in malignant and premalignant epithelia of Barrett's esophagus

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904773

Mutation of Asn-391 within the conserved NPXXY motif of the cholecystokinin B receptor abolishes Gq protein activation without affecting its association with the receptor

26 November 2018

1 reference

12 December 2020

Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo

1 reference

12 December 2020

Gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 and its association with Grb2 and the phosphatidylinositol 3-kinase

1 reference

12 December 2020

Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma

1 reference

12 December 2020

[Gastrin-17 and G17-gly induce proliferation of LoVo cells through the CCK B/gastrin receptor]

1 reference

12 December 2020

Gastrin stimulates the formation of a p60Src/p125FAK complex upstream of the phosphatidylinositol 3-kinase signaling pathway

1 reference

12 December 2020

10.1158/1541-7786.MCR-11-0483

Identifiers

DOI

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

22516348

1 reference