Alpha-secretase inhibition reduces human glioblastoma stem cell growth in vitro and in vivo by inhibiting Notch (Q30417011)

13 August 2017

Alpha-secretase inhibition reduces human glioblastoma stem cell growth in vitro and in vivo by inhibiting Notch (English)

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13 August 2017

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4

Olga Mykhaylyk

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13 August 2017

Desiree H Floyd

1

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13 August 2017

Benjamin Kefas

2

1 reference

13 August 2017

Oleksandr Seleverstov

3

1 reference

13 August 2017

Charli Dominguez

5

1 reference

13 August 2017

Laurey Comeau

6

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13 August 2017

Christian Plank

7

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13 August 2017

Benjamin Purow

8

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13 August 2017

7 September 2012

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13 August 2017

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13 August 2017

14

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13 August 2017

10

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13 August 2017

1215-1226

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Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Trafficking, acidification, and growth factor signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

ADAM17 regulates epidermal growth factor receptor expression through the activation of Notch1 in non-small cell lung cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Therapeutic antibody targeting of individual Notch receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

YKL-40: a novel marker shared by chronic inflammation and oncogenic transformation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Keeping mammalian mutation load in check: regulation of the activity of error-prone DNA polymerases by p53 and p21.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

The Ku antigen-recombination signal-binding protein Jkappa complex binds to the nuclear factor-kappaB p50 promoter and acts as a positive regulator of p50 expression in human gastric cancer cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Identification of a cancer stem cell in human brain tumors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Radial glial identity is promoted by Notch1 signaling in the murine forebrain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Signalling downstream of activated mammalian Notch

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Preparation and antitumor activity of o-palmitoyldextran phosphates, o-palmitoyldextrans, and dextran phosphate

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma.

20 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

Notch signaling in development and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

ADAM10 is essential for proteolytic activation of Notch during thymocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

Generation of magnetic nonviral gene transfer agents and magnetofection in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

YKL-40 and matrix metalloproteinase-9 as potential serum biomarkers for patients with high-grade gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

Regulation of YKL-40 expression during genotoxic or microenvironmental stress in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

Determining the LIF-sensitive period for implantation using a LIF-receptor antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FNEUONC%2FNOS157

Expression of the IL-6 family cytokines in human brain tumors.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3452340

Smooth Muscle alpha-actin is a direct target of Notch/CSL

26 November 2018

1 reference

12 December 2020

Elevated plasma YKL-40 predicts increased risk of gastrointestinal cancer and decreased survival after any cancer diagnosis in the general population

1 reference

12 December 2020

Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro

1 reference

12 December 2020

A simplified spectrophotometric determination of ester groups in lipids

1 reference

12 December 2020

Identifiers

DOI

10.1093/NEUONC/NOS157

1 reference

13 August 2017

1 reference

13 August 2017

1 reference