Therapeutic antibody targeting of individual Notch receptors (Q27660544)

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Carol Cain-Hom

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Lisa Choy

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Thijs J Hagenbeek

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Gladys P de Leon

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Yongmei Chen

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David Finkle

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Rayna Venook

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Xiumin Wu

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John Ridgway

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Dorreyah Schahin-Reed

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Graham J Dow

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Amy Shelton

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Scott Stawicki

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Ryan J Watts

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Jeff Zhang

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Robert Choy

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Peter Howard

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Lisa Kadyk

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Minhong Yan

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Jiping Zha

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Christopher A Callahan

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Sarah G Hymowitz

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Christian W Siebel

Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells.

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language of work or name

English

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publication date

15 April 2010

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published in

Nature

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volume

464

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issue

7291

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page(s)

1052-7

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cites work

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE08878

T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus

21 January 2018

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12 December 2020

Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma

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12 December 2020

p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas

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12 December 2020

Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules

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12 December 2020

Structural basis for autoinhibition of Notch

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12 December 2020

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

1 reference

12 December 2020

Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.

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12 December 2020

High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold

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12 December 2020

Substrate specificity of gamma-secretase and other intramembrane proteases

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12 December 2020

Notch signaling in leukemia

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12 December 2020

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

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12 December 2020

Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions

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12 December 2020

Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

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12 December 2020

Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma

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12 December 2020

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

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12 December 2020

The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling

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12 December 2020

Direct inhibition of the NOTCH transcription factor complex

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12 December 2020

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

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12 December 2020

The canonical Notch signaling pathway: unfolding the activation mechanism

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12 December 2020

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

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12 December 2020

Notch and cancer: a double-edged sword

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12 December 2020

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

1 reference

12 December 2020

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

1 reference

12 December 2020

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

1 reference

12 December 2020

NOTCH2 mutations in marginal zone lymphoma

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12 December 2020

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

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12 December 2020

Notch signaling, gamma-secretase inhibitors, and cancer therapy

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12 December 2020

X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling

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12 December 2020

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

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12 December 2020

Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

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12 December 2020

Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library

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12 December 2020

Recent insights into the role of Notch signaling in tumorigenesis

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12 December 2020

Angiogenesis: a team effort coordinated by notch.

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12 December 2020

Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas

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12 December 2020

Humanization of an anti-p185HER2 antibody for human cancer therapy

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12 December 2020

Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-beta receptor-IgG1 fusion protein.

1 reference

12 December 2020

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE08878

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1440145

1026135489

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1440145

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference