Counteracting chemical chaperone effects on the single-molecule α-synuclein structural landscape (Q30419579)

13 August 2017

Counteracting chemical chaperone effects on the single-molecule α-synuclein structural landscape (English)

1 reference

13 August 2017

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1 reference

Allan Chris M Ferreon

1

1 reference

13 August 2017

Mahdi Muhammad Moosa

2

1 reference

13 August 2017

Yann Gambin

3

1 reference

13 August 2017

Ashok A Deniz

4

1 reference

13 August 2017

language of work or name

English

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publication date

23 July 2012

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Proceedings of the National Academy of Sciences of the United States of America

13 August 2017

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13 August 2017

109

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13 August 2017

44

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13 August 2017

17826-17831

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Single-molecule views of protein movement on single-stranded DNA.

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Volume exclusion and H-bonding dominate the thermodynamics and solvation of trimethylamine-N-oxide in aqueous urea

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Chemical chaperones assist intracellular folding to buffer mutational variations.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

How, when and why proteins collapse: the relation to folding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Entropic stabilization of proteins by TMAO

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Osmolyte effects on protein stability and solubility: a balancing act between backbone and side-chains.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Visualization of the nanospring dynamics of the IkappaBalpha ankyrin repeat domain in real time

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Protein folding at single-molecule resolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

From the Cover: Charge interactions can dominate the dimensions of intrinsically disordered proteins.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Chaperonin-catalyzed rescue of kinetically trapped states in protein folding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Osmolyte-induced folding of an intrinsically disordered protein: folding mechanism in the absence of ligand

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Rescue of glaucoma-causing mutant myocilin thermal stability by chemical chaperones

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Theoretical perspectives on protein folding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Counteraction of urea by trimethylamine N-oxide is due to direct interaction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Trimethylamine N-oxide influence on the backbone of proteins: an oligoglycine model

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

High-resolution temperature-concentration diagram of alpha-synuclein conformation obtained from a single Förster resonance energy transfer image in a microfluidic device

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Direct single-molecule observation of a protein living in two opposed native structures

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Ligand-dependent equilibrium fluctuations of single calmodulin molecules

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Structure and energetics of the hydrogen-bonded backbone in protein folding.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Do-it-yourself guide: how to use the modern single-molecule toolkit

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Protein folding studied by single-molecule FRET.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Molecular basis of osmolyte effects on protein and metabolites

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Single-molecule biophysics: at the interface of biology, physics and chemistry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

The effects of cosolutes on protein dynamics: the reversal of denaturant-induced protein fluctuations by trimethylamine N-oxide

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Single-molecule fluorescence studies of protein folding and conformational dynamics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Protein-solvent interactions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Measuring the stability of partly folded proteins using TMAO.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Coupling of folding and binding for unstructured proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Trimethylamine oxide counteracts effects of hydrostatic pressure on proteins of deep-sea teleosts

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Structural stability of binding sites: consequences for binding affinity and allosteric effects.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Single-molecule protein folding: diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Osmolyte-driven contraction of a random coil protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Trimethylamine-N-oxide counteracts urea effects on rabbit muscle lactate dehydrogenase function: a test of the counteraction hypothesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Induced folding in RNA-protein recognition: more than a simple molecular handshake

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Natural osmolyte trimethylamine N-oxide stimulates tubulin polymerization and reverses urea inhibition.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Influence of molecular and chemical chaperones on protein folding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Organic solutes in freezing tolerance

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Navigating the folding routes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Living with water stress: evolution of osmolyte systems

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Protein denaturation. C. Theoretical models for the mechanism of denaturation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Urea and guanidine hydrochloride denaturation of ribonuclease, lysozyme, alpha-chymotrypsin, and beta-lactoglobulin.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Renal medullary organic osmolytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

Counteraction of urea destabilization of protein structure by methylamine osmoregulatory compounds of elasmobranch fishes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3497778

A practical guide on how osmolytes modulate macromolecular properties.

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1201802109

Organic Solutes in Freezing Tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1201802109

Trimethylamine N-oxide-induced cooperative folding of an intrinsically unfolded transcription-activating fragment of human glucocorticoid receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1201802109

Alpha-synuclein multistate folding thermodynamics: implications for protein misfolding and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1201802109

Trimethylamine-N-oxide-induced folding of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1201802109

Single-molecule fluorescence studies of intrinsically disordered proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1201802109

Additive transfer free energies of the peptide backbone unit that are independent of the model compound and the choice of concentration scale

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1201802109

Hydrogen Exchange Kinetics of RNase A and the Urea:TMAO Paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1201802109

Natural osmolytes remodel the aggregation pathway of mutant huntingtin exon 1

21 January 2018

1 reference

12 December 2020

An X-ray and neutron scattering study of the equilibrium between trimethylamine N-oxide and urea in aqueous solution

1 reference

12 December 2020

Predominant osmotically active organic solutes in rat and rabbit renal medullas

1 reference

12 December 2020

Forcing thermodynamically unfolded proteins to fold

1 reference

12 December 2020

Urea: diverse functions of a 'waste' product

1 reference

12 December 2020

The relationship of structure to the effectiveness of denaturing agents for proteins

1 reference

12 December 2020

Metrics that differentiate the origins of osmolyte effects on protein stability: a test of the surface tension proposal

1 reference

12 December 2020

Destabilization and stabilization of proteins

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1201802109

1 reference

13 August 2017

0 references

1 reference

13 August 2017

1 reference