A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies (Q30431388)

6 November 2017

A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies (English)

1 reference

antineoplastic resistance

6 November 2017

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

author name string

Joel Picus

4

1 reference

6 November 2017

Zhanfang Guo

17

1 reference

6 November 2017

Yu Tao

19

1 reference

6 November 2017

Shi-Rong Cai

21

1 reference

6 November 2017

Li Lin

22

1 reference

6 November 2017

Janet Dancey

23

1 reference

6 November 2017

Helen Piwnica-Worms

26

1 reference

6 November 2017

Paula M. Fracasso

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Kerry J. Williams

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Ronald C. Chen

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Cynthia X. Ma

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Matthew J. Ellis

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Benjamin R. Tan

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Timothy J. Pluard

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Douglas R. Adkins

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Michael J. Naughton

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Janet S. Rader

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Matthew A. Arquette

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

James W. Fleshman

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Allison N. Creekmore

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Sherry A. Goodner

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Lisa P. Wright

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Christine E. Ryan

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Eliane M. Soares

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Michelle A. Rudek

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

Howard L. McLeod

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

19 June 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20694727

19 June 2024

publication date

8 August 2010

1 reference

full work available at URL

6 November 2017

https://link.springer.com/content/pdf/10.1007/s00280-010-1410-1.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20694727/?tool=EBI

19 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20694727/pdf/?tool=EBI

19 June 2024

file format

Portable Document Format

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

https://europepmc.org/articles/PMC3102212

19 June 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

https://europepmc.org/articles/PMC3102212?pdf=render

19 June 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20694727

http://www.springerlink.com/index/pdf/10.1007/s00280-010-1410-1

19 June 2024

1 reference

10.1007/S00280-010-1410-1

DOI

https://api.crossref.org/works/10.1007/S00280-010-1410-1

Cancer Chemotherapy and Pharmacology

19 June 2024

published in

1 reference

6 November 2017

67

1 reference

6 November 2017

6

1 reference

6 November 2017

1225-1237

1 reference

describes a project that uses

6 November 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3102212/fullTextXML

inferred from PubMed Central ID database lookup

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The cyclin-dependent kinase inhibitor UCN-01 plus cisplatin in advanced solid tumors: a California cancer consortium phase I pharmacokinetic and molecular correlative trial

20 June 2018

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

20 June 2018

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Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints

20 June 2018

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20 June 2018

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20 June 2018

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Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma

20 June 2018

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20 June 2018

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20 June 2018

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Repeated observation of breast tumor subtypes in independent gene expression data sets

20 June 2018

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Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

20 June 2018

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20 June 2018

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Protein kinase C inhibition by UCN-01 induces apoptosis in human glioma cells in a time-dependent fashion

20 June 2018

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UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line

20 June 2018

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20 June 2018

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UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

20 June 2018

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20 June 2018

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Participation of p53 protein in the cellular response to DNA damage

20 June 2018

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20 June 2018

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UCN-01 (7-hydroxystaurosporine) inhibits the growth of human breast cancer xenografts through disruption of signal transduction

20 June 2018

1 reference

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7-hydroxystaurosporine (UCN-01) inhibition of Akt Thr308 but not Ser473 phosphorylation: a basis for decreased insulin-stimulated glucose transport

21 January 2018

1 reference

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Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

21 January 2018

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Effects of alpha1-acid glycoprotein on the clinical pharmacokinetics of 7-hydroxystaurosporine

21 January 2018

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Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic cata

21 January 2018

1 reference

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UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

21 January 2018

1 reference

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UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.

21 January 2018

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Highly synchronous culture of fibroblasts from G2 block caused by staurosporine, a potent inhibitor of protein kinases

21 January 2018

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Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

21 January 2018

1 reference

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A phase I and pharmacokinetic study of short infusions of UCN-01 in patients with refractory solid tumors

21 January 2018

1 reference

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Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.

26 November 2018

1 reference

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In vitro binding and partitioning of irinotecan (CPT-11) and its metabolite, SN-38, in human blood

26 November 2018

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12 December 2020

UCN-01 and camptothecin induce DNA double-strand breaks in p53 mutant tumor cells, but not in normal or p53 negative epithelial cells

1 reference

12 December 2020

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1 reference

12 December 2020

Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms

1 reference

12 December 2020

The protein kinase C inhibitor Gö6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints

1 reference

12 December 2020

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities

1 reference

12 December 2020

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells

1 reference

12 December 2020

Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells

1 reference

12 December 2020

Reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma

1 reference

12 December 2020

Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function

1 reference

12 December 2020

Clinical pharmacology of UCN-01: initial observations and comparison to preclinical models

1 reference

12 December 2020

Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor

1 reference

12 December 2020

Modulation of cell cycle progression in human tumors: a pharmacokinetic and tumor molecular pharmacodynamic study of cisplatin plus the Chk1 inhibitor UCN-01 (NSC 638850)

1 reference

12 December 2020

Phase I and pharmacokinetic study of 7-hydroxystaurosporine and carboplatin in advanced solid tumors

1 reference

12 December 2020

Altered pharmacokinetics of a novel anticancer drug, UCN-01, caused by specific high affinity binding to alpha1-acid glycoprotein in humans

1 reference

12 December 2020

Differential effects of UCN-01, staurosporine and CGP 41 251 on cell cycle progression and CDC2/cyclin B1 regulation in A431 cells synchronized at M phase by nocodazole

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of a novel protein kinase inhibitor, UCN-01

1 reference

12 December 2020

Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase path

1 reference

12 December 2020

Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G(2) arrest

1 reference

12 December 2020

Nederlands Tijdschrift voor Geneeskunde

2

145

602

MD Abramoff

2001

1 reference

10.1007/S00280-010-1410-1

DOI

https://api.crossref.org/works/10.1007/S00280-010-1410-1

10.1007/S00280-010-1410-1

19 June 2024

Identifiers

DOI

1 reference

Dimensions Publication ID

6 November 2017

0 references

1 reference

6 November 2017

1 reference