The alternative heart: impact of alternative splicing in heart disease (Q30432053)

21 June 2017

title

The alternative heart: impact of alternative splicing in heart disease (English)

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alternative mRNA splicing, via spliceosome

21 June 2017

main subject

1 reference

1 reference

Enrique Lara-Pezzi

1

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Alberto Gatto

object named as

Alberto Gatto

series ordinal

3

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author name string

Jesús Gómez-Salinero

series ordinal

2

1 reference

21 June 2017

Pablo García-Pavía

series ordinal

4

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21 June 2017

language of work or name

English

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publication date

18 June 2013

1 reference

Journal of Cardiovascular Translational Research

21 June 2017

published in

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21 June 2017

volume

6

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21 June 2017

issue

6

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21 June 2017

page(s)

945-955

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Understanding cardiovascular disease: a journey through the genome (and what we found there).

21 June 2017

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Regulation of alternative splicing: more than just the ABCs

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Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2.

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Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls

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Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins

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Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly

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Dynamic integration of splicing within gene regulatory pathways

21 January 2018

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hnRNP L and hnRNP A1 induce extended U1 snRNA interactions with an exon to repress spliceosome assembly

21 January 2018

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Regulation of alternative splicing by histone modifications

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Deciphering the splicing code

21 January 2018

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A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart

21 January 2018

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MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development

21 January 2018

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Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules

21 January 2018

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Heart failure-associated changes in RNA splicing of sarcomere genes

21 January 2018

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Calcineurin splicing variant calcineurin Aβ1 improves cardiac function after myocardial infarction without inducing hypertrophy.

21 January 2018

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Alpha-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: a disease of the sarcomere

21 January 2018

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Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy

21 January 2018

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A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy

21 January 2018

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A Single Troponin T Gene Regulated by Different Programs in Cardiac and Skeletal Muscle Development

21 January 2018

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The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing

21 January 2018

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CUGBP2 directly interacts with U2 17S snRNP components and promotes U2 snRNA binding to cardiac troponin T pre-mRNA.

21 January 2018

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ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle

21 January 2018

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Tropomyosin isoforms: divining rods for actin cytoskeleton function

21 January 2018

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Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform

21 January 2018

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Cardiac myosin binding protein-C gene splice acceptor site mutation is associated with familial hypertrophic cardiomyopathy

21 January 2018

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Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy

21 January 2018

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Evidence from human myectomy samples that MYBPC3 mutations cause hypertrophic cardiomyopathy through haploinsufficiency

21 January 2018

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EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Passive stiffness changes caused by upregulation of compliant titin isoforms in human dilated cardiomyopathy hearts

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Truncations of titin causing dilated cardiomyopathy.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy

21 January 2018

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Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy

21 January 2018

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E-peptides control bioavailability of IGF-1.

21 January 2018

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Enhancing repair of the mammalian heart

21 January 2018

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IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines.

21 January 2018

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mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart.

21 January 2018

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Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction.

21 January 2018

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Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle

21 January 2018

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A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration

21 January 2018

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A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

21 January 2018

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Molecular diversity of VEGF-A as a regulator of its biological activity.

21 January 2018

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Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

21 January 2018

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Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis

21 January 2018

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Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

21 January 2018

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X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Biodesign of a renal-protective peptide based on alternative splicing of B-type natriuretic peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Increased expression of alternatively spliced dominant-negative isoform of SRF in human failing hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Alternative splicing of T-box transcription factor genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Distinct expression and function of alternatively spliced Tbx5 isoforms in cell growth and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Functional role of transcriptional factor TBX5 in pre-mRNA splicing and Holt-Oram syndrome via association with SC35.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Alternatively spliced IS6 segments of the alpha 1C gene determine the tissue-specific dihydropyridine sensitivity of cardiac and vascular smooth muscle L-type Ca2+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Replacement of the muscle-specific sarcoplasmic reticulum Ca(2+)-ATPase isoform SERCA2a by the nonmuscle SERCA2b homologue causes mild concentric hypertrophy and impairs contraction-relaxation of the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

An intronic mutation causes long QT syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Pre-mRNA splicing in disease and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

A muscleblind knockout model for myotonic dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Transgenic mice expressing CUG-BP1 reproduce splicing mis-regulation observed in myotonic dystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

A conserved splicing mechanism of the LMNA gene controls premature aging.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Lamin A-dependent nuclear defects in human aging

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

21 January 2018

Overview on AON design

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https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Targeting nuclear RNA for in vivo correction of myotonic dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

The status of exon skipping as a therapeutic approach to duchenne muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Pip6-PMO, A New Generation of Peptide-oligonucleotide Conjugates With Improved Cardiac Exon Skipping Activity for DMD Treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Systemic administration of PRO051 in Duchenne's muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Rescue of dystrophic muscle through U7 snRNA-mediated exon skipping

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Splice modulating therapies for human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Antitumorigenic potential of STAT3 alternative splicing modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

The evolutionary landscape of alternative splicing in vertebrate species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-013-9482-Z

Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy

21 January 2018

1 reference

12 December 2020

Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms

1 reference

12 December 2020

Splicing mutations in KCNQ1: a mutation hot spot at codon 344 that produces in frame transcripts

1 reference

12 December 2020

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

1 reference

12 December 2020

Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes

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12 December 2020

Dynamic antagonism between ETR-3 and PTB regulates cell type-specific alternative splicing

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12 December 2020

10.1007/S12265-013-9482-Z

Identifiers

DOI

1 reference

Dimensions Publication ID

21 June 2017

1052883431

0 references

Fatcat ID

release_2sn3xbdwqne6zl5pn46eoewftm

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2sn3xbdwqne6zl5pn46eoewftm

24 November 2022

mapped directly with Wikidata item

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