Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone (Q30439859)

18 August 2017

Pharmacologic inhibition of the TGF-beta type I receptor kinase has anabolic and anti-catabolic effects on bone (English)

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18 August 2017

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Tamara Alliston

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Larry J Suva

object named as

Larry J Suva

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Theresa A Guise

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object named as

Theresa A Guise

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18 August 2017

Khalid S Mohammad

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18 August 2017

Carol G Chen

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18 August 2017

Guive Balooch

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18 August 2017

Elizabeth Stebbins

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18 August 2017

C Ryan McKenna

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18 August 2017

Holly Davis

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18 August 2017

Maria Niewolna

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18 August 2017

Xiang Hong Peng

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18 August 2017

Daniel H N Nguyen

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18 August 2017

Sophi S Ionova-Martin

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18 August 2017

John W Bracey

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18 August 2017

William R Hogue

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18 August 2017

Darren H Wong

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18 August 2017

Robert O Ritchie

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18 August 2017

Rik Derynck

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18 August 2017

language of work or name

English

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publication date

16 April 2008

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18 August 2017

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18 August 2017

4

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18 August 2017

e5275

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18 August 2017

4

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Creative Commons Attribution 4.0 International

18 August 2017

start time

16 April 2009

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease

20 June 2018

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Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness

20 June 2018

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A biomechanical perspective on bone quality.

20 June 2018

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Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure.

20 June 2018

1 reference

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Regulation of bone mass by Wnt signaling

20 June 2018

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TGF-beta regulates the mechanical properties and composition of bone matrix

20 June 2018

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The relationship between the stiffness and the mineral content of bone

20 June 2018

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Current insights into the role of transforming growth factor-beta in bone resorption.

20 June 2018

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Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

20 June 2018

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Transforming growth factor-beta1 to the bone

20 June 2018

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BMP signaling in skeletal development

20 June 2018

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Development of TGF-beta signalling inhibitors for cancer therapy

20 June 2018

1 reference

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SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666804

Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-beta regulation of osteoclast differentiation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666804

Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

20 June 2018

1 reference

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Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542

20 June 2018

1 reference

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Effect of insulin-like growth factor-1 (IGF-1) plus alendronate on bone density during puberty in IGF-1-deficient MIDI mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666804

Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666804

The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666804

Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-beta (TGF-beta). Mapping of the OPG promoter region that mediates TGF-beta effects

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666804

TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666804

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666804

The design of mineralised hard tissues for their mechanical functions.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666804

Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666804

Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666804

Decreased bone mass and bone elasticity in mice lacking the transforming growth factor-beta1 gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2666804

Osteoblastic responses to TGF-beta during bone remodeling

20 June 2018

1 reference

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Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype

20 June 2018

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Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin

20 June 2018

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Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

20 June 2018

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Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor

20 June 2018

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Transforming growth factor-beta receptor type 1 (TGFbetaRI) kinase activity but not p38 activation is required for TGFbetaRI-induced myofibroblast differentiation and profibrotic gene expression.

21 January 2018

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Proteolysis of latent transforming growth factor-beta (TGF-beta )-binding protein-1 by osteoclasts. A cellular mechanism for release of TGF-beta from bone matrix.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005275

Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005275

Effects of cyclic versus daily hPTH(1-34) regimens on bone strength in association with BMD, biochemical markers, and bone structure in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005275

Bisphosphonates stimulate formation of osteoblast precursors and mineralized nodules in murine and human bone marrow cultures in vitro and promote early osteoblastogenesis in young and aged mice in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005275

Measurement of hardness and elastic modulus by instrumented indentation: Advances in understanding and refinements to methodology

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005275

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0005275

Activation of the bone-derived latent TGF beta complex by isolated osteoclasts

21 January 2018

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12 December 2020

Osteoclast synthesis and secretion and activation of latent transforming growth factor beta

1 reference

12 December 2020

Three-dimensional mapping of mineral densities in carious dentin: theory and method

1 reference

12 December 2020

Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation

1 reference

12 December 2020

Transforming growth factor-beta1 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic/stromal cells and inhibits the survival of murine osteoclast-like cells

1 reference

12 December 2020

Elastic modulus and hardness of cortical and trabecular bone lamellae measured by nanoindentation in the human femur

1 reference

12 December 2020

Inhibin A is an endocrine stimulator of bone mass and strength

1 reference

12 December 2020

Endogenous production of TGF-beta is essential for osteoclastogenesis induced by a combination of receptor activator of NF-kappa B ligand and macrophage-colony-stimulating factor

1 reference

12 December 2020

Transforming growth factor-beta controls human osteoclastogenesis through the p38 MAPK and regulation of RANK expression

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0005275

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DOI

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18 August 2017

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18 August 2017

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