TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage (Q36342408)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11285272%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

title

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage (English)

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6 November 2019

1 reference

1

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6 November 2019

author name string

L Chen

2

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6 November 2019

X Xu

3

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6 November 2019

C Li

4

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6 November 2019

C Huang

5

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6 November 2019

C X Deng

6

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6 November 2019

language of work or name

English

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publication date

1 April 2001

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6 November 2019

published in

Journal of Cell Biology

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6 November 2019

volume

153

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6 November 2019

page(s)

35-46

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6 November 2019

issue

1

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The family of bone morphogenetic proteins

6 November 2019

cites work

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

30 September 2017

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Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis

30 September 2017

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30 September 2017

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MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

30 September 2017

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30 September 2017

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Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

30 September 2017

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MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily

30 September 2017

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30 September 2017

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30 September 2017

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29 June 2018

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29 June 2018

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Opposite effects of osteogenic protein and transforming growth factor beta on chondrogenesis in cultured long bone rudiments.

29 June 2018

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29 June 2018

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Localization of the expression of types I, III, and IV collagen, TGF-beta 1 and c-fos genes in developing human calvarial bones

29 June 2018

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29 June 2018

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29 June 2018

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29 June 2018

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29 June 2018

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29 June 2018

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29 June 2018

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Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes.

22 September 2018

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Immunolocalization of transforming growth factor-beta s and type I and type II receptors in rat articular cartilage.

22 September 2018

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Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning.

22 September 2018

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Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily.

22 September 2018

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Autocrine or paracrine transforming growth factor-beta modulates the phenotype of chick embryo sternal chondrocytes in serum-free agarose culture.

22 September 2018

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Proteoglycan loss and subsequent replenishment in articular cartilage after a mild arthritic insult by IL-1 in mice: impaired proteoglycan turnover in the recovery phase

22 September 2018

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Matrix degradation by chondrocytes cultured in alginate: IL-1 beta induces proteoglycan degradation and proMMP synthesis but does not result in collagen degradation

22 September 2018

1 reference

12 December 2020

Chondrocyte-mediated catabolism of aggrecan: evidence for a glycosylphosphatidylinositol-linked protein in the aggrecanase response to interleukin-1 or retinoic acid

1 reference

12 December 2020

Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification

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12 December 2020

The regulation of MMPs and TIMPs in cartilage turnover

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12 December 2020

Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections

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12 December 2020

A 55-year-old woman with rheumatoid arthritis

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12 December 2020

[TGF-beta-1 gene transfer in joint cartilage cells. Stimulating effect in extracellular matrix synthesis]

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12 December 2020

Differential effects of transforming growth factors beta 1, beta 2, beta 3 and beta 5 on chondrogenesis in mouse limb bud mesenchymal cells

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12 December 2020

Immunoreactive localization of transforming growth factor-beta type II receptor-positive cells in rat tibiae

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12 December 2020

Reduced cartilage proteoglycan loss during zymosan-induced gonarthritis in NOS2-deficient mice and in anti-interleukin-1-treated wild-type mice with unabated joint inflammation

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12 December 2020

In situ hybridization analysis of TGF beta 3 RNA expression during mouse development: comparative studies with TGF beta 1 and beta 2

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12 December 2020

Osteoarthritic human cartilage is more sensitive to transforming growth factor beta than is normal cartilage

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12 December 2020

TGF-beta 1 prevents hypertrophy of epiphyseal chondrocytes: regulation of gene expression for cartilage matrix proteins and metalloproteases

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12 December 2020

Transforming growth factor-beta 1 stimulates articular chondrocyte proteoglycan synthesis and induces osteophyte formation in the murine knee joint

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12 December 2020

Terminal differentiation of chondrocytes in culture is a spontaneous process and is arrested by transforming growth factor-beta 2 and basic fibroblast growth factor in synergy

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12 December 2020

Growth factors in experimental osteoarthritis: transforming growth factor beta pathogenic?

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12 December 2020

Long bone geometry and strength in adult BMP-5 deficient mice

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12 December 2020

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning

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12 December 2020

Differential expression of membrane-anchored proteoglycans in rabbit articular chondrocytes cultured in monolayers and in alginate beads. Effect of transforming growth factor-beta 1

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12 December 2020

Signal transduction by bone morphogenetic proteins

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12 December 2020

Identifiers

DOI

10.1083/JCB.153.1.35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11285272%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11285272%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11285272%20AND%20SRC:MED&resulttype=core&format=json