Phosphorylation of p130Cas initiates Rac activation and membrane ruffling (Q30441108)

17 August 2017

Phosphorylation of p130Cas initiates Rac activation and membrane ruffling (English)

1 reference

17 August 2017

1 reference

Alok Sharma

1

1 reference

PMCID

2553404

17 August 2017

Bruce J Mayer

series ordinal

2

1 reference

17 August 2017

15 September 2008

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17 August 2017

1 reference

17 August 2017

9

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17 August 2017

50

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Creative Commons Attribution 2.0 Generic

17 August 2017

start time

15 September 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

exact match

https://scigraph.springernature.com/pub.10.1186/1471-2121-9-50

0 references

cites work

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Flux at focal adhesions: slippage clutch, mechanical gauge, or signal depot

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Big roles for small GTPases in the control of directed cell movement

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Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas

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20 June 2018

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20 June 2018

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Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerization

20 June 2018

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Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

20 June 2018

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Regulation of substrate adhesion dynamics during cell motility

20 June 2018

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SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading

20 June 2018

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Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold

20 June 2018

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The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling

20 June 2018

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20 June 2018

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Functions of the adapter protein Cas: signal convergence and the determination of cellular responses

20 June 2018

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Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src

20 June 2018

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Focal adhesions: structure and dynamics

20 June 2018

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IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

20 June 2018

1 reference

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Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics

20 June 2018

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Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix

20 June 2018

1 reference

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New roles for Src kinases in control of cell survival and angiogenesis

20 June 2018

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A heterodimeric coiled-coil peptide pair selected in vivo from a designed library-versus-library ensemble.

20 June 2018

1 reference

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Potentiation of cell migration by adhesion-dependent cooperative signals from the GTPase Rac and Raf kinase

20 June 2018

1 reference

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Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells

20 June 2018

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Src family kinases are required for integrin but not PDGFR signal transduction.

20 June 2018

1 reference

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Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

20 June 2018

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Essential roles for the Abl and Arg tyrosine kinases in neurulation

20 June 2018

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Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas

20 June 2018

1 reference

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CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

20 June 2018

1 reference

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Cellular functions regulated by Src family kinases

20 June 2018

1 reference

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Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes

20 June 2018

1 reference

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Regulation of cell motility by mitogen-activated protein kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

20 June 2018

Actin dynamics in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Integrins: emerging paradigms of signal transduction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Regulation, substrates and functions of src

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Cell migration: a physically integrated molecular process

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Ornithine decarboxylase- and ras-induced cell transformations: reversal by protein tyrosine kinase inhibitors and role of pp130CAS.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Characterization, partial purification, and peptide sequencing of p130,the main phosphoprotein associated with v-Crk oncoprotein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Adhesion-induced tyrosine phosphorylation of the p130 src substrate

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Regulation and localization of CAS substrate domain tyrosine phosphorylation

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2553404

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18793427

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p130(Cas), an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblasts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18793427

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An Examination of Focal Adhesion Formation and Tyrosine Phosphorylation in Fibroblasts Isolated from src¯, fyn¯, and yes¯ Mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18793427

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1471-2121-9-50

1 reference

PMCID

2553404

Dimensions Publication ID

17 August 2017

0 references

1 reference

17 August 2017

1 reference

PMCID

2553404