Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1. (Q30441983)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11352944%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1 (English)

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7 November 2019

1

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7 November 2019

Vladimir L. Gabai

3

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7 November 2019

author name string

K Mabuchi

2

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7 November 2019

J A Yaglom

4

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7 November 2019

A Kazantsev

5

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7 November 2019

M Y Sherman

6

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7 November 2019

language of work or name

English

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publication date

1 May 2001

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7 November 2019

published in

Journal of Cell Biology

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7 November 2019

volume

153

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7 November 2019

issue

4

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7 November 2019

page(s)

851-864

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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

7 November 2019

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Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

20 June 2018

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20 June 2018

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20 June 2018

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Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line

20 June 2018

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MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

20 June 2018

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Transglutaminase action imitates Huntington's disease: selective polymerization of Huntingtin containing expanded polyglutamine.

20 June 2018

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Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

20 June 2018

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Pericentrin and gamma-tubulin form a protein complex and are organized into a novel lattice at the centrosome

20 June 2018

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MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis

20 June 2018

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

20 June 2018

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Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

20 June 2018

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Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: relevance to diseases of the nervous system

20 June 2018

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Heat shock causes protein aggregation and reduced protein solubility at the centrosome and other cytoplasmic locations

20 June 2018

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20 June 2018

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Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

20 June 2018

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Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac.

20 June 2018

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Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin

20 June 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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HLA-DR beta chains enter into an aggregated complex containing GRP-78/BiP prior to their degradation by the pre-Golgi degradative pathway

20 June 2018

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20 June 2018

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Identification of gamma-tubulin, a new member of the tubulin superfamily encoded by mipA gene of Aspergillus nidulans.

20 June 2018

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Protein aggregation and inclusion body formation in Escherichia coli rpoH mutant defective in heat shock protein induction.

20 June 2018

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Heat-shock-induced denaturation of proteins. Characterization of the insolubilization of the interferon-induced p68 kinase

20 June 2018

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Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

20 June 2018

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Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera

26 November 2018

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Biosynthesis and degradation of CFTR.

26 November 2018

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Transglutaminase as the agent of neurodegenerative diseases due to polyglutamine expansion.

26 November 2018

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Transgenic mice in the study of polyglutamine repeat expansion diseases.

26 November 2018

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

26 November 2018

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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

26 November 2018

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26 November 2018

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Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

26 November 2018

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12 December 2020

Properties of abnormal proteins degraded rapidly in reticulocytes. Intracellular aggregation of the globin molecules prior to hydrolysis

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Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

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Activity and regulation of the centrosome-associated proteasome

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Triggering of neuronal cell death by accumulation of activated SEK1 on nuclear polyglutamine aggregations in PML bodies

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Identifiers

DOI

10.1083/JCB.153.4.851

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11352944%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11352944%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference