Random mutagenesis of Helicobacter pylori vacA to identify amino acids essential for vacuolating cytotoxic activity. (Q30445265)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16954403%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

title

Random mutagenesis of Helicobacter pylori vacA to identify amino acids essential for vacuolating cytotoxic activity (English)

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29 December 2019

1 reference

1

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29 December 2019

Victor J. Torres

3

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29 December 2019

Timothy L. Cover

6

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29 December 2019

author name string

Daniel M Czajkowsky

2

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29 December 2019

Gabor Szabo

4

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29 December 2019

Zhifeng Shao

5

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29 December 2019

language of work or name

English

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publication date

5 September 2006

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29 December 2019

published in

Infection and Immunity

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29 December 2019

volume

74

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issue

11

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29 December 2019

page(s)

6188-6195

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Mimicry of a host anion channel by a Helicobacter pylori pore-forming toxin

29 December 2019

cites work

1 reference

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Helicobacter pylori VacA, a paradigm for toxin multifunctionality

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Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion

20 June 2018

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Targeting of Helicobacter pylori vacuolating toxin to lipid raft membrane domains analysed by atomic force microscopy

20 June 2018

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Membrane channel structure of Helicobacter pylori vacuolating toxin: role of multiple GXXXG motifs in cylindrical channels.

20 June 2018

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Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation

20 June 2018

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20 June 2018

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20 June 2018

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Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor

20 June 2018

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A 12-amino-acid segment, present in type s2 but not type s1 Helicobacter pylori VacA proteins, abolishes cytotoxin activity and alters membrane channel formation

20 June 2018

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Outer membrane targeting of passenger proteins by the vacuolating cytotoxin autotransporter of Helicobacter pylori

20 June 2018

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Antigenic diversity among Helicobacter pylori vacuolating toxins

20 June 2018

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Living dangerously: how Helicobacter pylori survives in the human stomach

20 June 2018

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Amino-terminal hydrophobic region of Helicobacter pylori vacuolating cytotoxin (VacA) mediates transmembrane protein dimerization.

20 June 2018

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Vacuolating cytotoxin of Helicobacter pylori plays a role during colonization in a mouse model of infection

20 June 2018

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Carboxy-terminal proteolytic processing of Helicobacter pylori vacuolating toxin.

20 June 2018

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Expression and binding analysis of GST-VacA fusions reveals that the C-terminal approximately 100-residue segment of exotoxin is crucial for binding in HeLa cells

20 June 2018

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Mutational analysis of the Helicobacter pylori vacuolating toxin amino terminus: identification of amino acids essential for cellular vacuolation

20 June 2018

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Natural diversity in the N terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity.

20 June 2018

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The GxxxG motif: a framework for transmembrane helix-helix association

20 June 2018

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Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta.

20 June 2018

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Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity.

20 June 2018

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VacA from Helicobacter pylori: a hexameric chloride channel

20 June 2018

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The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH.

20 June 2018

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Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation.

20 June 2018

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TOXCAT: a measure of transmembrane helix association in a biological membrane

20 June 2018

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Identification of the Helicobacter pylori VacA toxin domain active in the cell cytosol

20 June 2018

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20 June 2018

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Helicobacter pylori vacuolating cytotoxin binds to the 140-kDa protein in human gastric cancer cell lines, AZ-521 and AGS.

20 June 2018

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Acid-induced dissociation of VacA, the Helicobacter pylori vacuolating cytotoxin, reveals its pattern of assembly

20 June 2018

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Introduction of unmarked mutations in the Helicobacter pylori vacA gene with a sucrose sensitivity marker

20 June 2018

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Binding and internalization of the Helicobacter pylori vacuolating cytotoxin by epithelial cells

20 June 2018

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An efficient random mutagenesis technique using an E. coli mutator strain

20 June 2018

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Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease

20 June 2018

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Cytotoxic activity in broth-culture filtrates of Campylobacter pylori

20 June 2018

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Proton-translocating ATPases

20 June 2018

1 reference

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Effect of urease on HeLa cell vacuolation induced by Helicobacter pylori cytotoxin

20 June 2018

1 reference

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Purification and characterization of the vacuolating toxin from Helicobacter pylori

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1695532

Co-ordinate expression of virulence genes by ToxR in Vibrio cholerae

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1695532

Mapping of a domain required for protein-protein interactions and inhibitory activity of a Helicobacter pylori dominant-negative VacA mutant protein.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1695532

Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin.

26 November 2018

1 reference

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The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms.

26 November 2018

1 reference

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Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1695532

Essential role of a GXXXG motif for membrane channel formation by Helicobacter pylori vacuolating toxin

26 November 2018

1 reference

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Helicobacter pyloriInfection

26 November 2018

1 reference

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Association of Helicobacter pylori vacuolating toxin (VacA) with lipid rafts

26 November 2018

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The ClC-3 chloride channel promotes acidification of lysosomes in CHO-K1 and Huh-7 cells

26 November 2018

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Vacuolation induced by VacA toxin of Helicobacter pylori requires the intracellular accumulation of membrane permeant bases, Cl(-) and water

26 November 2018

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Helicobacter pylori vacuolating cytotoxin binding to a putative cell surface receptor, heparan sulfate, studied by surface plasmon resonance

26 November 2018

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3D imaging of the 58 kDa cell binding subunit of the Helicobacter pylori cytotoxin

26 November 2018

1 reference

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The acid activation of Helicobacter pylori toxin VacA: structural and membrane binding studies

26 November 2018

1 reference

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Lipid interaction of the 37-kDa and 58-kDa fragments of the Helicobacter pylori cytotoxin.

26 November 2018

1 reference

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Interactions between p-33 and p-55 Domains of theHelicobacter pyloriVacuolating Cytotoxin (VacA)

26 November 2018

1 reference

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A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation

26 November 2018

1 reference

12 December 2020

Functional complementation reveals the importance of intermolecular monomer interactions for Helicobacter pylori VacA vacuolating activity

1 reference

12 December 2020

Oxonol VI as an optical indicator for membrane potentials in lipid vesicles

1 reference

12 December 2020

Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant

1 reference

12 December 2020

Vacuolation induced by cytotoxin from Helicobacter pylori is mediated by the EGF receptor in HeLa cells

1 reference

12 December 2020

Identification of the minimal intracellular vacuolating domain of the Helicobacter pylori vacuolating toxin

1 reference

12 December 2020

Helicobacter pylori VacA toxin: a tool to study novel early endosomes

1 reference

12 December 2020

Identifiers

DOI

10.1128/IAI.00915-06

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16954403%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16954403%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

16954403

1 reference