Statins in liver disease: a molehill, an iceberg, or neither? (Q30446668)

21 June 2017

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title

Statins in liver disease: a molehill, an iceberg, or neither? (English)

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21 June 2017

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Amedeo Lonardo

4

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author name string

Curtis K Argo

series ordinal

1

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21 June 2017

Paola Loria

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2

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21 June 2017

Stephen H Caldwell

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3

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21 June 2017

language of work or name

English

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publication date

1 August 2008

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21 June 2017

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21 June 2017

48

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21 June 2017

662-669

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21 June 2017

2

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Updated definitions of healthy ranges for serum alanine aminotransferase levels

21 June 2017

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

21 January 2018

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Pravastatin and the development of diabetes mellitus: evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study

21 January 2018

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Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis

21 January 2018

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Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease: an open question.

21 January 2018

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7 January 2021

Differences and similarities in early atherosclerosis between patients with non-alcoholic steatohepatitis and chronic hepatitis B and C

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7 January 2021

Hyperlipidaemic state and cardiovascular risk in primary biliary cirrhosis

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7 January 2021

Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity

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7 January 2021

Statins for non-alcoholic fatty liver disease: a new indication?

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7 January 2021

Statins and liver toxicity: a meta-analysis

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7 January 2021

Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease: Results of a prospective, randomized, double-blind, placebo-controlled, multicenter trial

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7 January 2021

Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines

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7 January 2021

Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events

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7 January 2021

Relationship between high-sensitivity C-reactive protein levels and liver histology in subjects with non-alcoholic fatty liver disease

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7 January 2021

Effects of simvastatin, pentoxifylline and spironolactone on hepatic fibrosis and portal hypertension in rats with bile duct ligation

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7 January 2021

Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase

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7 January 2021

Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis.

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7 January 2021

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions

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7 January 2021

Impact of statin dosing intensity on transaminase and creatine kinase

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7 January 2021

Are statins created equal? Evidence from randomized trials of pravastatin, simvastatin, and atorvastatin for cardiovascular disease prevention

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7 January 2021

Lipid and non-lipid effects of statins

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7 January 2021

Reduction of oxidative stress and modulation of autoantibodies against modified low-density lipoprotein after rosuvastatin therapy

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7 January 2021

Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis

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7 January 2021

The ability of statins to protect low density lipoprotein from oxidation in hypercholesterolemic patients.

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7 January 2021

Liver X receptors as integrators of metabolic and inflammatory signaling

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7 January 2021

Statins and transcriptional regulation: the FXR connection

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7 January 2021

Statins and hepatic steatosis: perspectives from the Dallas Heart Study

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7 January 2021

Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells

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7 January 2021

Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status

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7 January 2021

Lipid metabolism in the liver.

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7 January 2021

Gene expression profiling in livers of mice after acute inhibition of beta-oxidation.

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7 January 2021

Regulation of bile acid synthesis in humans: effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7 alpha-hydroxylation rates in vivo

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7 January 2021

Effects of combined treatment with pravastatin and ursodeoxycholic acid on hepatic cholesterol metabolism.

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7 January 2021

The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism

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7 January 2021

Endocrine functions of bile acids

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7 January 2021

Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin.

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7 January 2021

The tissue biology of ductular reactions in human chronic liver disease

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7 January 2021

Inhibition of Hedgehog signaling protects adult mice from diet-induced weight gain

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7 January 2021

Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells

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7 January 2021

Review article: the metabolic syndrome and non-alcoholic fatty liver disease

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7 January 2021

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity

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7 January 2021

Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease.

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7 January 2021

Carotid artery intima-media thickness in nonalcoholic fatty liver disease

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7 January 2021

Cause-specific mortality in type 2 diabetes. The Verona Diabetes Study

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7 January 2021

Nonalcoholic fatty liver disease in patients with type 2 diabetes

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7 January 2021

Long-term follow-up of patients with NAFLD and elevated liver enzymes

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7 January 2021

Medical significance of peroxisome proliferator-activated receptors.

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7 January 2021

Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages

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7 January 2021

Atorvastatin reverses age-related reduction in rat hepatic PPARalpha and HNF-4

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7 January 2021

The effect of atorvastatin on erythrocyte membranes and serum lipids in patients with type-2 hypercholesterolemia

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7 January 2021

Effect of pravastatin and atorvastatin on glucose metabolism in nondiabetic patients with hypercholesterolemia

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7 January 2021

Beyond insulin resistance in NASH: TNF-alpha or adiponectin?

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7 January 2021

High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH.

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7 January 2021

Review article: hepatic steatosis and insulin resistance

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7 January 2021

Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease

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7 January 2021

The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes

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7 January 2021

Statins induce calcium-dependent mitochondrial permeability transition

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7 January 2021

HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage.

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7 January 2021

International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D recept

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7 January 2021

Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor.

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7 January 2021

Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells

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7 January 2021

Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets

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7 January 2021

Pravastatin in patients with nonalcoholic steatohepatitis: results of a pilot study

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7 January 2021

A pilot study of atorvastatin treatment in dyslipemid, non-alcoholic fatty liver patients

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7 January 2021

Rosuvastatin as a novel treatment of non-alcoholic fatty liver disease in hyperlipidemic patients.

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7 January 2021

Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: a histopathological follow-up study

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7 January 2021

Dysmetabolic changes associated with HCV: a distinct syndrome?

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7 January 2021

Genotype-specific mechanisms for hepatic steatosis in chronic hepatitis C infection.

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7 January 2021

Long-term reversal of hypocholesterolaemia in patients with chronic hepatitis C is related to sustained viral response and viral genotype

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7 January 2021

Correlation between beta-lipoprotein levels and outcome of hepatitis C treatment

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7 January 2021

Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts

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7 January 2021

Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids

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7 January 2021

Different anti-HCV profiles of statins and their potential for combination therapy with interferon

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7 January 2021

Lowering Plasma Cholesterol by Raising LDL Receptors

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7 January 2021

Low density lipoprotein receptor as a candidate receptor for hepatitis C virus

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7 January 2021

Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease

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7 January 2021

Atorvastatin does not exhibit antiviral activity against HCV at conventional doses: a pilot clinical trial

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7 January 2021

Simvastatin in primary biliary cirrhosis: effects on serum lipids and distinct disease markers

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7 January 2021

Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid

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7 January 2021

The effects of HMG-CoA reductase inhibitor on vascular progenitor cells.

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7 January 2021

The pro- and antiangiogenic effects of statins

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7 January 2021

Biphasic effect of HMG-CoA reductase inhibitor, pitavastatin, on vascular endothelial cells and angiogenesis

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7 January 2021

Class-specific pro-apoptotic effect of statins on human vascular endothelial cells

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7 January 2021

Hypothesis: the antitumor activities of statins may be mediated by IL-18

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7 January 2021

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA.

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7 January 2021

Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins.

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7 January 2021

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

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7 January 2021

Identifiers

DOI

10.1002/HEP.22402

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21 June 2017

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