The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling (Q30480823)

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English	The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling	scientific article

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scholarly article

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Europe PubMed Central

13 August 2017

The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling (English)

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Europe PubMed Central

13 August 2017

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author name string

Dana M Brantley-Sieders

1

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Europe PubMed Central

13 August 2017

Guanglei Zhuang

2

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Europe PubMed Central

13 August 2017

Donna Hicks

3

1 reference

Europe PubMed Central

13 August 2017

Wei Bin Fang

4

1 reference

Europe PubMed Central

13 August 2017

Yoonha Hwang

5

1 reference

Europe PubMed Central

13 August 2017

Justin M M Cates

6

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Europe PubMed Central

13 August 2017

Karen Coffman

7

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Europe PubMed Central

13 August 2017

Dowdy Jackson

8

1 reference

Europe PubMed Central

13 August 2017

Elizabeth Bruckheimer

9

1 reference

Europe PubMed Central

13 August 2017

Rebecca S Muraoka-Cook

10

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Europe PubMed Central

13 August 2017

Jin Chen

11

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Europe PubMed Central

13 August 2017

language of work or name

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publication date

1 January 2008

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Europe PubMed Central

13 August 2017

Journal of Clinical Investigation

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Europe PubMed Central

13 August 2017

118

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Europe PubMed Central

13 August 2017

1

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Europe PubMed Central

13 August 2017

64-78

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Europe PubMed Central

13 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2129239/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Activation of the EGFR gene target EphA2 inhibits epidermal growth factor-induced cancer cell motility

1 reference

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20 June 2018

Efficacy and antivascular effects of EphA2 reduction with an agonistic antibody in ovarian cancer

1 reference

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20 June 2018

A novel mechanism for p53 to regulate its target gene ECK in signaling apoptosis

1 reference

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20 June 2018

Expression profiling of UVB response in melanocytes identifies a set of p53-target genes

1 reference

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20 June 2018

Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin

1 reference

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20 June 2018

Anti-EphA2 antibodies decrease EphA2 protein levels in murine CT26 colorectal and human MDA-231 breast tumors but do not inhibit tumor growth

1 reference

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20 June 2018

Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression

1 reference

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20 June 2018

A conditional feedback loop regulates Ras activity through EphA2.

1 reference

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20 June 2018

Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery

1 reference

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20 June 2018

Eph receptor signalling casts a wide net on cell behaviour

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics.

1 reference

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20 June 2018

Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors

1 reference

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20 June 2018

Eph receptor tyrosine kinases in tumor and tumor microenvironment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Decreased tumorigenic potential of EphA2-overexpressing breast cancer cells following treatment with adenoviral vectors that express EphrinA1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Eph receptor tyrosine kinases in angiogenesis: from development to disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Cancer genes and the pathways they control

1 reference

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20 June 2018

Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Inhibition of VEGF-dependent multistage carcinogenesis by soluble EphA receptors

1 reference

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20 June 2018

Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Progression to Malignancy in the Polyoma Middle T Oncoprotein Mouse Breast Cancer Model Provides a Reliable Model for Human Diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

'Eph'ective signaling: forward, reverse and crosstalk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Rules for making human tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Negative regulation of EphA2 receptor by Cbl.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis

1 reference

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Evidence of high incidence of EGFRvIII expression and coexpression with EGFR in human invasive breast cancer by laser capture microdissection and immunohistochemical analysis

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A system for stable expression of short interfering RNAs in mammalian cells

1 reference

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20 June 2018

ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Cell transformation by the middle T-antigen of polyoma virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Timing of cyclin D1 expression within G1 phase is controlled by Rho.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Nuclear factor-kappaB (NF-kappaB) regulates proliferation and branching in mouse mammary epithelium

1 reference

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20 June 2018

Oncogenic kinase signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

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Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

1 reference

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Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Signal transduction in mammary tumorigenesis: a transgenic perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

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E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

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In vivo properties of three human HER2/neu-expressing murine cell lines in immunocompetent mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

20 June 2018

The Clinical Significance of Epidermal Growth Factor Receptor (EGF-R) in Human Breast Cancer: A Review on 5232 Patients*

1 reference

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Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

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Silencing the receptor EphA2 suppresses the growth and haptotaxis of malignant mesothelioma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

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A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

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EGFR and EGFRvIII expression in primary breast cancer and cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

EphA2: a determinant of malignant cellular behavior and a potential therapeutic target in pancreatic adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

Antiangiogenic and antitumor efficacy of EphA2 receptor antagonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

Ligand binding up-regulates EphA2 messenger RNA through the mitogen-activated protein/extracellular signal-regulated kinase pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

Apoptotic Response to 5-Fluorouracil Treatment Is Mediated by Reduced Polyamines, Non-Autocrine Fas Ligand and Induced Tumor Necrosis Factor Receptor 2

1 reference

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26 November 2018

EphA2 overexpression decreases estrogen dependence and tamoxifen sensitivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

Prognostic value of the combination of epidermal growth factor receptor and c-erbB-2 in breast cancer

1 reference

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26 November 2018

c-Cbl-dependent EphA2 protein degradation is induced by ligand binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

EphA2 overexpression causes tumorigenesis of mammary epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

Tumor necrosis factor-alpha induction of endothelial ephrin A1 expression is mediated by a p38 MAPK- and SAPK/JNK-dependent but nuclear factor-kappa B-independent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2129239

26 November 2018

Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18079969

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18079969

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insights from transgenic mouse models of ERBB2-induced breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18079969

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammary gland specific hEGF receptor transgene expression induces neoplasia and inhibits differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18079969

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prognostic value of epidermal growth factor receptor (EGF-R) in primary breast cancer: results of a 10 year follow-up study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18079969

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI33154

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Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

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