NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis (Q30497993)

17 October 2017

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis (English)

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17 October 2017

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Justin A MacDonald

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Paul L Beck

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object named as

Paul L Beck

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17 October 2017

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Jurg Tschopp

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17 October 2017

Simon A Hirota

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17 October 2017

Jeffrey Ng

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17 October 2017

Alan Lueng

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17 October 2017

Maitham Khajah

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17 October 2017

Ken Parhar

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17 October 2017

Yan Li

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17 October 2017

Victor Lam

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17 October 2017

Mireille S Potentier

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17 October 2017

Kelvin Ng

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17 October 2017

Misha Bawa

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17 October 2017

Donna-Marie McCafferty

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17 October 2017

Kevin P Rioux

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17 October 2017

Subrata Ghosh

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17 October 2017

Ramnik J Xavier

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17 October 2017

Sean P Colgan

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17 October 2017

Daniel Muruve

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24 September 2010

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Inflammatory Bowel Diseases

17 October 2017

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17 October 2017

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17 October 2017

1359-1372

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17 October 2017

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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

17 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Nod2 is required for the regulation of commensal microbiota in the intestine

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Dysregulation of human beta-defensin-2 protein in inflammatory bowel disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Phagocyte dysfunction and inflammatory bowel disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Phenotype-genotype analysis of cryopyrin-associated periodic syndromes (CAPS): description of a rare non-exon 3 and a novel CIAS1 missense mutation.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Chronic stimulation of Nod2 mediates tolerance to bacterial products

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

The inflammasome: a danger sensing complex triggering innate immunity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Cryopyrin-associated periodic syndromes and autoinflammation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Unravelling the pathogenesis of inflammatory bowel disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Defensins and cathelicidins in gastrointestinal infections

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Defective acute inflammation in Crohn's disease: a clinical investigation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Neutrophil chemotaxis in a patient with neonatal-onset multisystem inflammatory disease and Muckle-Wells syndrome.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Dysbiosis in inflammatory bowel disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

The in vitro production and characterization of neutrophils from embryonic stem cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Dextran sulfate sodium-induced colonic histopathology, but not altered epithelial ion transport, is reduced by inhibition of phosphodiesterase activity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Characterization of microbial diversity by determining terminal restriction fragment length polymorphisms of genes encoding 16S rRNA.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Immunosuppressive and anti-inflammatory properties of interleukin 10.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Quantitative aspects of the production of superoxide radicals by phagocytizing human granulocytes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations

14 July 2018

1 reference

Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.

21 January 2018

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Paradoxical roles of different nitric oxide synthase isoforms in colonic injury.

21 January 2018

1 reference

DNA isolation protocols affect the detection limit of PCR approaches of bacteria in samples from the human gastrointestinal tract

21 January 2018

1 reference

Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

21 January 2018

1 reference

Detection of muramyl dipeptide-sensing pathway defects in patients with Crohnʼs disease

21 January 2018

1 reference

Reduced alpha-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease.

21 January 2018

1 reference

Ribosomal DNA sequence analysis of mucosa-associated bacteria in Crohn's disease

21 January 2018

1 reference

Reduced sensitivity of inducible nitric oxide synthase-deficient mice to chronic colitis

21 January 2018

1 reference

Fecal beta-defensin-2 in children with inflammatory bowel diseases

21 January 2018

1 reference

Enhanced human beta-defensin-2 (hBD-2) expression by corticosteroids is independent of NF-kappaB in colonic epithelial cells (CaCo2).

21 January 2018

1 reference

Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis.

21 January 2018

1 reference

Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn's disease

21 January 2018

1 reference

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

21 January 2018

1 reference

Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

NOD2 3020insC mutation and the pathogenesis of Crohn's disease: impaired IL-1beta production points to a loss-of-function phenotype.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Caspase-1-deficient mice have delayed neutrophil apoptosis and a prolonged inflammatory response to lipopolysaccharide-induced acute lung injury.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026862

Optimal storage conditions for preserving granulocyte viability as monitored by Annexin V binding in whole blood

26 November 2018

1 reference

12 December 2020

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis

1 reference

12 December 2020

Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease

1 reference

12 December 2020

Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation

1 reference

12 December 2020

The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4

1 reference

12 December 2020

Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways

1 reference

12 December 2020

Blockade of TGF-beta accelerates mucosal destruction through epithelial cell apoptosis

1 reference

12 December 2020

Activation of toll-like receptor 3 protects against DSS-induced acute colitis

1 reference

12 December 2020

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

1 reference

12 December 2020

beta-Defensin-3 and -4 in intestinal epithelial cells display increased mRNA expression in ulcerative colitis

1 reference

12 December 2020

Inhibition of alveolar neutrophil immigration in endotoxemia is macrophage inflammatory protein 2 independent

1 reference

12 December 2020

Hapten-induced model of chronic inflammation and ulceration in the rat colon

1 reference

12 December 2020

Identifiers

DOI

10.1002/IBD.21478

1 reference

17 October 2017

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17 October 2017

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