NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes (Q42526336)

1 November 2017

title

NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes (English)

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1 November 2017

Vanessa Beynon

1

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Sebastian Cotofana

2

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Stephan Brand

3

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1 November 2017

Peter Lohse

4

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Anja Mair

5

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Stefanie Wagner

6

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Thomas Mussack

7

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Thomas Ochsenkühn

8

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1 November 2017

Matthias Folwaczny

9

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Christian Folwaczny

10

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Jürgen Glas

11

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Helga-Paula Török

12

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publication date

1 August 2008

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Inflammatory Bowel Diseases

1 November 2017

published in

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1 November 2017

volume

14

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1 November 2017

issue

8

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1 November 2017

page(s)

1033-1040

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Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities

1 November 2017

cites work

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Mapping of a susceptibility locus for Crohn's disease on chromosome 16

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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Crohn's disease and the NOD2 gene: a role for paneth cells

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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 January 2018

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Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease

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Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

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Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan

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Inflammatory Bowel Disease

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Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations

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NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease

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Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease

21 January 2018

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Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

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NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

21 January 2018

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Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation

21 January 2018

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A genome-wide association study identifies IL23R as an inflammatory bowel disease gene

21 January 2018

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21 January 2018

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rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants

21 January 2018

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Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.

21 January 2018

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Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study.

21 January 2018

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Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists

21 January 2018

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Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

21 January 2018

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NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction

21 January 2018

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Chronic stimulation of Nod2 mediates tolerance to bacterial products

21 January 2018

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Celecoxib inhibits interleukin-12 alphabeta and beta2 folding and secretion by a novel COX2-independent mechanism involving chaperones of the endoplasmic reticulum.

21 January 2018

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Calreticulin is a binding protein for muramyl dipeptide and peptidoglycan in RK13 cells

21 January 2018

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Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

21 January 2018

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Proinflammatory and immunoregulatory functions of interleukin-12.

21 January 2018

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Antibodies to interleukin 12 abrogate established experimental colitis in mice

21 January 2018

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Interleukin-12 and the regulation of innate resistance and adaptive immunity

21 January 2018

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Responses to self and non-self intestinal microflora in health and inflammatory bowel disease

21 January 2018

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Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IBD.20441

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1 November 2017

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