Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure. (Q30498104)

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English	Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure.	scientific article

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17 January 2020

Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure (English)

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17 January 2020

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Hans-Georg Joost

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17 January 2020

Stephan Scherneck

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17 January 2020

Annette Schürmann

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17 January 2020

author name string

O Kluth

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17 January 2020

F Mirhashemi

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17 January 2020

D Kaiser

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17 January 2020

R Kluge

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17 January 2020

S Neschen

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17 January 2020

publication date

24 November 2010

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17 January 2020

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17 January 2020

54

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17 January 2020

605-616

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17 January 2020

3

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17 January 2020

https://scigraph.springernature.com/pub.10.1007/s00125-010-1973-8

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Current perspectives on Akt Akt-ivation and Akt-ions

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28 July 2018

Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL

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28 July 2018

The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress.

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28 July 2018

Beta-cell failure as a complication of diabetes

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28 July 2018

Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice

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28 July 2018

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

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28 July 2018

Role of FoxO Proteins in Pancreatic beta Cells

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28 July 2018

Did the gradual loss of GLUT2 cause a shift to diabetic disorders in the New Zealand obese mouse (NZO/Hl)?

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28 July 2018

Regulation of the insulin gene by glucose and fatty acids

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28 July 2018

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

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28 July 2018

Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells

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28 July 2018

Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome

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28 July 2018

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

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28 July 2018

Beta-cell adaptation and decompensation during the progression of diabetes.

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28 July 2018

Direct control of the Forkhead transcription factor AFX by protein kinase B

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28 July 2018

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

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28 July 2018

Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion

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28 July 2018

Glucose toxicity

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28 July 2018

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

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28 July 2018

High-fat, carbohydrate-free diet markedly aggravates obesity but prevents beta-cell loss and diabetes in the obese, diabetes-susceptible db/db strain

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26 November 2018

Transcription factors involved in glucose-stimulated insulin secretion of pancreatic beta cells

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26 November 2018

Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity

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26 November 2018

A meta-analysis of QTL for diabetes-related traits in rodents.

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26 November 2018

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

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26 November 2018

Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice.

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26 November 2018

Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis.

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26 November 2018

Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes

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26 November 2018

Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat.

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26 November 2018

Gradual loss of pancreatic beta-cell insulin, glucokinase and GLUT2 glucose transporter immunoreactivities during the time course of nutritionally induced type-2 diabetes in Psammomys obesus (sand rat).

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26 November 2018

beta-cell glucotoxicity in the Psammomys obesus model of type 2 diabetes

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26 November 2018

Type 2 diabetes-like hyperglycemia in a backcross model of NZO and SJL mice: characterization of a susceptibility locus on chromosome 4 and its relation with obesity.

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26 November 2018

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.

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26 November 2018

Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction

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12 December 2020

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A metabolic syndrome of hypertension, hyperinsulinaemia and hypercholesterolaemia in the New Zealand obese mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/21107520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21107520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Laboratory animals exhibiting obesity and diabetes syndromes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21107520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of Dietary Carbohydrate on the Induction of Diabetes in C57BL/KsJ-db/db Diabetes Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21107520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An improved method for isolation of mouse pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/21107520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of the binding domain of the inhibitory ligand forskolin in the glucose transporter GLUT-4 by photolabeling, proteolytic cleavage and a site-specific antiserum

1 reference

https://pubmed.ncbi.nlm.nih.gov/21107520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of GLUT2 glucose transporter expression in pancreatic beta cells from diabetic Chinese hamsters

1 reference

https://pubmed.ncbi.nlm.nih.gov/21107520

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds

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12 December 2020

based on heuristic

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Identifiers

10.1007/S00125-010-1973-8

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17 January 2020

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17 January 2020

1 reference

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17 January 2020

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