Current perspectives on Akt Akt-ivation and Akt-ions (Q37549664)

21 August 2017

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title

Current perspectives on Akt Akt-ivation and Akt-ions (English)

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21 August 2017

Ronald W Matheny

1

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PubMed ID

19596822

21 August 2017

Martin L Adamo

series ordinal

2

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21 August 2017

13 July 2009

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Experimental Biology and Medicine

21 August 2017

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21 August 2017

234

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21 August 2017

1264-1270

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21 August 2017

11

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Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

21 August 2017

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Signaling by distinct classes of phosphoinositide 3-kinases

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Oncogenic signaling of class I PI3K isoforms.

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Two splice variants of protein kinase B gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site serine 472 in the carboxyl-terminal hydrophobic domain

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Role of translocation in the activation and function of protein kinase B

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

AKT/PKB signaling: navigating downstream

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Nicotine inactivation of the proapoptotic function of Bax through phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Dynamic FoxO transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

PKB and the mitochondria: AKTing on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

The AMP-activated protein kinase cascade--a unifying system for energy control

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Physiological roles of PKB/Akt isoforms in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Distinct roles of the three Akt isoforms in lactogenic differentiation and involution

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Deregulated Akt3 activity promotes development of malignant melanoma

21 January 2018

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https://api.crossref.org/works/10.3181%2F0904-MR-138

Activation of Akt2 Inhibits anoikis and apoptosis induced by myogenic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

Development of pyridopyrimidines as potent Akt1/2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3181%2F0904-MR-138

21 January 2018

Identifiers

DOI

10.3181/0904-MR-138

1 reference

21 August 2017

1 reference

PubMed ID

19596822