FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion (Q30499286)

19 October 2017

FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion (English)

1 reference

19 October 2017

1 reference

Therese B Deramaudt

1

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19 October 2017

Denis Dujardin

2

1 reference

19 October 2017

Abdelkader Hamadi

3

1 reference

19 October 2017

Fanny Noulet

4

1 reference

19 October 2017

Kaouther Kolli

5

1 reference

19 October 2017

Jan De Mey

6

1 reference

19 October 2017

Kenneth Takeda

7

1 reference

19 October 2017

Philippe Rondé

8

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19 October 2017

2 February 2011

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Molecular Biology of the Cell

19 October 2017

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19 October 2017

22

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19 October 2017

7

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19 October 2017

964-975

1 reference

describes a project that uses

19 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3069021/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Hyperphosphorylated FAK Delocalizes from Focal Adhesions to Membrane Ruffles

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Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

20 June 2018

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20 June 2018

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A role for the juxtamembrane cytoplasm in the molecular dynamics of focal adhesions

20 June 2018

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Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

20 June 2018

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Src activation and translocation from focal adhesions to membrane ruffles contribute to formation of new adhesion sites

20 June 2018

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Comparative dynamics of retrograde actin flow and focal adhesions: formation of nascent adhesions triggers transition from fast to slow flow

20 June 2018

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Phosphorylation of p130Cas initiates Rac activation and membrane ruffling

20 June 2018

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Investigating complexity of protein-protein interactions in focal adhesions

20 June 2018

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RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells

20 June 2018

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FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts

20 June 2018

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Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity

20 June 2018

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20 June 2018

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Structural basis for the autoinhibition of focal adhesion kinase

20 June 2018

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Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases

20 June 2018

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Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics

20 June 2018

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Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration

20 June 2018

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Integrating adhesion, protrusion, and contraction during cell migration

20 June 2018

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Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion

20 June 2018

1 reference

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Rho GTPases and the control of cell behaviour

20 June 2018

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Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397.

20 June 2018

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The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

20 June 2018

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Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells

20 June 2018

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Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior

20 June 2018

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Regulation of cell motility by tyrosine phosphorylated villin

20 June 2018

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SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling

20 June 2018

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Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations

20 June 2018

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Multiple connections link FAK to cell motility and invasion

20 June 2018

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Calcium rises locally trigger focal adhesion disassembly and enhance residency of focal adhesion kinase at focal adhesions

20 June 2018

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Newest findings on the oldest oncogene; how activated src does it

20 June 2018

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FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

20 June 2018

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NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model

20 June 2018

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Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration

20 June 2018

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Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction

20 June 2018

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Focal adhesion kinase: the first ten years

20 June 2018

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Differential regulation of cell motility and invasion by FAK

20 June 2018

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EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).

20 June 2018

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The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly

20 June 2018

1 reference

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The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin

20 June 2018

1 reference

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pp60(c-src) and related tyrosine kinases: a role in the assembly and reorganization of matrix adhesions.

20 June 2018

1 reference

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Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases.

20 June 2018

1 reference

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Paxillin binding is not the sole determinant of focal adhesion localization or dominant-negative activity of focal adhesion kinase/focal adhesion kinase-related nonkinase

20 June 2018

1 reference

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FAK integrates growth-factor and integrin signals to promote cell migration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration

20 June 2018

1 reference

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Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion

20 June 2018

1 reference

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Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates

20 June 2018

1 reference

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Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src.

20 June 2018

1 reference

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Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

20 June 2018

1 reference

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p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Cytoskeletal dynamics and nerve growth

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Becoming stable and strong: the interplay between vinculin exchange dynamics and adhesion strength during adhesion site maturation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

New Insights into FAK Signaling and Localization Based on Detection of a FAT Domain Folding Intermediate

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

The focal adhesion targeting domain of focal adhesion kinase contains a hinge region that modulates tyrosine 926 phosphorylation

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

ERK 1/2- and JNKs-dependent synthesis of interleukins 6 and 8 by fibroblast-like synoviocytes stimulated with protein I/II, a modulin from oral streptococci, requires focal adhesion kinase.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Calcium oscillations trigger focal adhesion disassembly in human U87 astrocytoma cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3069021

Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21289086

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1091/MBC.E10-08-0725

1 reference

19 October 2017

1 reference

19 October 2017

1 reference