Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memory (Q30504501)

3 September 2017

Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memory (English)

1 reference

3 September 2017

3

Michelle C Potter

1 reference

3 September 2017

Ana Pocivavsek

1

1 reference

3 September 2017

Hui-Qiu Wu

2

1 reference

3 September 2017

Greg I Elmer

4

1 reference

3 September 2017

Roberto Pellicciari

5

1 reference

3 September 2017

Robert Schwarcz

6

1 reference

3 September 2017

language of work or name

English

0 references

publication date

27 July 2011

1 reference

3 September 2017

Neuropsychopharmacology

1 reference

3 September 2017

36

1 reference

3 September 2017

11

1 reference

3 September 2017

2357-2367

1 reference

RG3487, a novel nicotinic α7 receptor partial agonist, improves cognition and sensorimotor gating in rodents.

3 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Thinking Glutamatergically: Changing Concepts of Schizophrenia Based Upon Changing Neurochemical Models

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

The Hippocampal Formation in Schizophrenia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Do astrocytes really exocytose neurotransmitters?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Glutamatergic modulatory therapy for Tourette syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Recent advances in the treatment of amyotrophic lateral sclerosis. Emphasis on kynurenine pathway inhibitors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Gliotransmission: Exocytotic release from astrocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Structure, expression, and function of kynurenine aminotransferases in human and rodent brains

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Second-by-second analysis of alpha 7 nicotine receptor regulation of glutamate release in the prefrontal cortex of awake rats

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Clinical application of measurement of hippocampal atrophy in degenerative dementias

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Mammalian nicotinic acetylcholine receptors: from structure to function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

NMDA receptors in clinical neurology: excitatory times ahead

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

The substrates of memory: defects, treatments, and enhancement

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Schizophrenia and the alpha7 nicotinic acetylcholine receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Antisense knockdown of the rat alpha7 nicotinic acetylcholine receptor produces spatial memory impairment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Kynurenic acid leads, dopamine follows: a new case of volume transmission in the brain?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Elevations of endogenous kynurenic acid produce spatial working memory deficits

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Alzheimer's disease-related alterations in synaptic density: neocortex and hippocampus.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

The drugs don't work-or do they? Pharmacological and transgenic studies of the contribution of NMDA and GluR-A-containing AMPA receptors to hippocampal-dependent memory.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Behavioural pharmacology: 40+ years of progress, with a focus on glutamate receptors and cognition

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Role of kynurenines in the central and peripheral nervous systems

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Kynurenine 3-mono-oxygenase inhibitors reduce glutamate concentration in the extracellular spaces of the basal ganglia but not in those of the cortex or hippocampus

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Astrocytic control of glutamatergic activity: astrocytes as stars of the show

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Unconventional ligands and modulators of nicotinic receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Increased cortical kynurenate content in schizophrenia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Kynurenine metabolism in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

3-[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Brain-specific modulation of kynurenic acid synthesis in the rat.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Hippocampal synaptic transmission enhanced by low concentrations of nicotine.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Long-term potentiation and glutamate release in the dentate gyrus: links to spatial learning

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Developments of a water-maze procedure for studying spatial learning in the rat

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Identification and quantification of kynurenic acid in human brain tissue.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Presence of Kynurenic Acid in the Mammalian Brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Determination of extracellular kynurenic acid in the striatum of unanesthetized rats: effect of aminooxyacetic acid.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Effects of NMDA receptor antagonists on passive avoidance learning and retrieval in rats and mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Nicotinylalanine increases the formation of kynurenic acid in the brain and antagonizes convulsions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Kynurenic acid: a potential pathogen in brain disorders.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

A behavioral analysis of the spatial learning deficit induced by the NMDA receptor antagonist MK-801 (dizocilpine) in the rat.

20 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Indirect modulation by alpha7 nicotinic acetylcholine receptors of noradrenaline release in rat hippocampal slices: interaction with glutamate and GABA systems and effect of nicotine withdrawal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

The novel alpha7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Presynaptic kynurenate-sensitive receptors inhibit glutamate release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Increased concentration of cerebral kynurenic acid alters stimulus processing and conditioned responding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Ongoing in vivo experience triggers synaptic metaplasticity in the neocortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

D-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Endogenous kynurenic acid disrupts prepulse inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neuropathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

The medial prefrontal cortex is involved in spatial memory retrieval under partial-cue conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

D-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

The partial alpha7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Sequence variants in kynurenine aminotransferase II (KAT II) orthologs determine different potencies of the inhibitor S-ESBA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Nicotine and D-cycloserine enhance acquisition of water maze spatial navigation in aged rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Micromolar Brain Levels of Kynurenic Acid are Associated with a Disruption of Auditory Sensory Gating in the Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPP.2011.127

Ultrastructural distribution of the alpha7 nicotinic acetylcholine receptor subunit in rat hippocampus.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3176574

Fluorimetric micro-determination of kynurenic acid, an endogenous blocker of neurotoxicity, by high-performance liquid chromatography

26 November 2018

1 reference

12 December 2020

Effects of intrastriatal blockade of glutamatergic transmission on the acquisition of T-maze and radial maze tasks

1 reference

12 December 2020

Modulation of extracellular kynurenic acid content by excitatory amino acids in primary cultures of rat astrocytes

1 reference

12 December 2020

Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization

1 reference

12 December 2020

Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of (S)-4-(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor

1 reference

12 December 2020

Identifiers

DOI

10.1038/NPP.2011.127

1 reference

Dimensions Publication ID

3 September 2017

0 references

1 reference

3 September 2017

PubMed publication ID

21796108

1 reference