Exploiting polypharmacology for drug target deconvolution (Q30575524)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24707051%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

title

Exploiting polypharmacology for drug target deconvolution (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24707051%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

1

1 reference

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13 March 2020

Leonid Peshkin

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24707051%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

author name string

Marc W Kirschner

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24707051%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

language of work or name

English

0 references

publication date

19 March 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24707051%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

13 March 2020

number of pages

6

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24707051%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

volume

111

1 reference

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13 March 2020

issue

13

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13 March 2020

page(s)

5048-5053

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24707051%20AND%20SRC:MED&resulttype=core&format=json

Polypharmacology - foe or friend?

13 March 2020

cites work

1 reference

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Target deconvolution techniques in modern phenotypic profiling.

20 June 2018

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Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

20 June 2018

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EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers

20 June 2018

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Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

20 June 2018

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Discoidin domain receptor 2 is a critical regulator of epithelial-mesenchymal transition.

20 June 2018

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Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

20 June 2018

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TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation

20 June 2018

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A systems view of epithelial-mesenchymal transition signaling states

20 June 2018

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Regularization Paths for Generalized Linear Models via Coordinate Descent

20 June 2018

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Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest

20 June 2018

1 reference

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Receptor tyrosine kinase coactivation networks in cancer

20 June 2018

1 reference

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A simplified method for quantifying cell migration/wound healing in 96-well plates

20 June 2018

1 reference

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Heterotrimerization of the growth factor receptors erbB2, erbB3, and insulin-like growth factor-i receptor in breast cancer cells resistant to herceptin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977247

NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint

20 June 2018

1 reference

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Cell cycle, CDKs and cancer: a changing paradigm

20 June 2018

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Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.

20 June 2018

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Network pharmacology: the next paradigm in drug discovery

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977247

A quantitative analysis of kinase inhibitor selectivity

20 June 2018

1 reference

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Gini coefficient: a new way to express selectivity of kinase inhibitors against a family of kinases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977247

Target deconvolution strategies in drug discovery

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977247

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

20 June 2018

1 reference

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Global mapping of pharmacological space

20 June 2018

1 reference

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Autocrine PDGFR signaling promotes mammary cancer metastasis

20 June 2018

1 reference

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ErbB4 increases the proliferation potential of human lung cancer cells and its blockage can be used as a target for anti-cancer therapy.

20 June 2018

1 reference

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Cell migration: integrating signals from front to back

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977247

Measurement of chondrocyte chemotaxis using a Boyden chamber: a model of receptor-mediated cell migration combined with cell sedimentation

20 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1403080111

EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1403080111

21 January 2018

Identifiers

DOI

10.1073/PNAS.1403080111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24707051%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24707051%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

PubMed publication ID

24707051

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24707051%20AND%20SRC:MED&resulttype=core&format=json