Autocrine PDGFR signaling promotes mammary cancer metastasis (Q24545375)

2

0 references

Richard Moriggl

object named as

Richard Moriggl

3

0 references

Martin Jechlinger

object named as

Martin Jechlinger

1

0 references

author name string

Peter Seither

4

0 references

Norbert Kraut

5

0 references

Paola Capodiecci

6

0 references

Michael Donovan

7

0 references

Hartmut Beug

9

0 references

Stefan Grünert

Journal of Clinical Investigation

10

0 references

language of work or name

English

0 references

publication date

June 2006

0 references

published in

0 references

volume

116

0 references

issue

6

0 references

page(s)

1561-70

0 references

cites work

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Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

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Involvement of chemokine receptors in breast cancer metastasis

24 March 2017

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The Hallmarks of Cancer

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Mechanism of action and in vivo role of platelet-derived growth factor

24 March 2017

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

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DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells

24 March 2017

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Role of transforming growth factor-beta signaling in cancer

24 March 2017

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ras oncogenes in human cancer: a review

24 March 2017

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Molecular requirements for epithelial-mesenchymal transition during tumor progression

7 April 2017

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Epithelial-mesenchymal transitions in development and pathologies

7 April 2017

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TGF-beta signaling in tumor suppression and cancer progression

7 April 2017

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An overview of epithelio-mesenchymal transformation

7 April 2017

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Epithelial-mesenchymal transition: NF-kappaB takes center stage

10 May 2017

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PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

27 September 2017

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NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

27 September 2017

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Epithelial-mesenchymal transitions: twist in development and metastasis

27 September 2017

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Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model.

27 September 2017

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Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

27 September 2017

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Expression profiling of epithelial plasticity in tumor progression

27 September 2017

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Mechanisms in epithelial plasticity and metastasis: insights from 3D cultures and expression profiling.

27 September 2017

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Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids

27 September 2017

1 reference

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PDGF receptors as cancer drug targets

27 September 2017

1 reference

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Effects of blocking platelet-derived growth factor-receptor signaling in a mouse model of experimental prostate cancer bone metastases

27 September 2017

1 reference

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Growth factor receptors in breast cancer: potential for therapeutic intervention.

27 September 2017

1 reference

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Pharmacology of imatinib (STI571).

27 September 2017

1 reference

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Oncogenic Ras/Her-2 mediate hyperproliferation of polarized epithelial cells in 3D cultures and rapid tumor growth via the PI3K pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

27 September 2017

1 reference

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Molecular mechanisms of "detachment-induced apoptosis--Anoikis".

27 September 2017

1 reference

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Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention

27 September 2017

1 reference

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DNA mismatch repair defects: role in colorectal carcinogenesis

27 September 2017

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Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

27 September 2017

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TGF-beta signaling in cancer--a double-edged sword

27 September 2017

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PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

27 September 2017

1 reference

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Induction and regulation of epithelial-mesenchymal transitions

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Dominant-negative mutations of platelet-derived growth factor (PDGF) receptors. Inhibition of receptor function by ligand-dependent formation of heterodimers between PDGF alpha- and beta-receptors.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Expression of functional human EGF receptor on murine bone marrow cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Platelet-derived growth factor is an autocrine stimulator for the growth and survival of human esophageal carcinoma cell lines

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Platelet‐derived growth factor‐B increases colon cancer cell growth in vivo by a paracrine effect

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Epithelial-mesenchymal transitions in cancer progression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Activated platelet-derived growth factor autocrine pathway drives the transformed phenotype of a human glioblastoma cell line

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Effects of an antibody to vascular endothelial growth factor receptor-2 on survival, tumor vascularity, and apoptosis in a murine model of colon carcinomatosis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Positive immunostaining for platelet derived growth factor (PDGF) is an adverse prognostic factor in patients with advanced breast cancer

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Establishment of mouse colonic carcinoma cell lines with different metastatic properties

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Platelet-derived growth factor (PDGF) in plasma of breast cancer patients: Correlation with stage and rate of progression

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Simultaneous blockade of platelet-derived growth factor-receptor and epidermal growth factor-receptor signaling and systemic administration of paclitaxel as therapy for human prostate cancer metastasis in bone of nude mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Flt-1-Dependent Survival Characterizes the Epithelial-Mesenchymal Transition of Colonic Organoids

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

RAF/RAS oncogenes and mismatch-repair status

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Inducible expression of transforming growth factor beta1 in papillomas causes rapid metastasis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Activation of STAT proteins and cytokine genes in human Th1 and Th2 cells generated in the absence of IL-12 and IL-4.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469776

Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer

28 November 2018

1 reference

12 December 2020

DPC4 gene in various tumor types

1 reference

12 December 2020

Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer

1 reference

12 December 2020

Expression of platelet-derived growth factor B-chain and the platelet-derived growth factor receptor beta subunit in human breast tissue and breast carcinoma

1 reference

12 December 2020