Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase (Q30658298)

10 August 2017

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase (English)

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10 August 2017

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3

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7 June 2020

Henrik Hammarén

5

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7 June 2020

Stevan R Hubbard

9

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7 June 2020

author name string

Yibing Shan

1

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7 June 2020

Kavitha Gnanasambandan

2

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7 June 2020

Eric T Kim

4

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7 June 2020

Kazuo Yamashita

6

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7 June 2020

Olli Silvennoinen

7

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7 June 2020

David E Shaw

8

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7 June 2020

publication date

11 June 2014

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Nature Structural & Molecular Biology

10 August 2017

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7 June 2020

volume

21

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7 June 2020

page(s)

579-584

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7 June 2020

issue

7

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

7 June 2020

cites work

1 reference

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Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

20 June 2018

1 reference

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Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

20 June 2018

1 reference

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Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4508010

Ab initio modeling and experimental assessment of Janus Kinase 2 (JAK2) kinase-pseudokinase complex structure

20 June 2018

1 reference

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Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone φ, ψ and side-chain χ(1) and χ(2) dihedral angles

20 June 2018

1 reference

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JAKs and STATs in immunity, immunodeficiency, and cancer

20 June 2018

1 reference

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JAK2 the future: therapeutic strategies for JAK-dependent malignancies

20 June 2018

1 reference

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Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

20 June 2018

1 reference

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The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

20 June 2018

1 reference

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New mutations and pathogenesis of myeloproliferative neoplasms.

20 June 2018

1 reference

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How does a drug molecule find its target binding site?

20 June 2018

1 reference

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The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617.

20 June 2018

1 reference

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Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805

20 June 2018

1 reference

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JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors

20 June 2018

1 reference

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Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases

20 June 2018

1 reference

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A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation

20 June 2018

1 reference

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JAK mutations in high-risk childhood acute lymphoblastic leukemia

20 June 2018

1 reference

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A conserved protonation-dependent switch controls drug binding in the Abl kinase

20 June 2018

1 reference

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Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4508010

Phosphorylation of JAK2 at serine 523: a negative regulator of JAK2 that is stimulated by growth hormone and epidermal growth factor.

20 June 2018

1 reference

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

20 June 2018

1 reference

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

20 June 2018

1 reference

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

20 June 2018

1 reference

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Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling

20 June 2018

1 reference

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Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity

20 June 2018

1 reference

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Structural basis for the autoinhibition of c-Abl tyrosine kinase

20 June 2018

1 reference

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The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

20 June 2018

1 reference

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The conformational plasticity of protein kinases

20 June 2018

1 reference

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Regulation of the Jak2 tyrosine kinase by its pseudokinase domain

20 June 2018

1 reference

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Canonical dynamics: Equilibrium phase-space distributions

20 June 2018

1 reference

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Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies

20 June 2018

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A simple reference state makes a significant improvement in near-native selections from structurally refined docking decoys

21 January 2018

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Protein Loop Modeling with Optimized Backbone Potential Functions.

21 January 2018

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Residue-residue potentials with a favorable contact pair term and an unfavorable high packing density term, for simulation and threading.

21 January 2018

1 reference

Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation

21 January 2018

1 reference

Regulation of JAK2 activation by Janus homology 2: evidence from molecular dynamics simulations.

21 January 2018

1 reference

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

A common, avoidable source of error in molecular dynamics integrators.

21 January 2018

1 reference

A fast SHAKE algorithm to solve distance constraint equations for small molecules in molecular dynamics simulations

21 January 2018

1 reference

Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors

21 January 2018

1 reference

Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors

21 January 2018

1 reference

Is the Ewald summation still necessary? Pairwise alternatives to the accepted standard for long-range electrostatics

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/NSMB.2849

1 reference

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Dimensions Publication ID

7 June 2020

0 references

1 reference

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7 June 2020

1 reference