The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617. (Q34316190)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20958061%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617 (English)

1 reference

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15 February 2020

2

1 reference

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15 February 2020

author name string

Kavitha Gnanasambandan

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20958061%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

Peter P Sayeski

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20958061%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

language of work or name

English

0 references

publication date

29 October 2010

1 reference

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15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20958061%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

volume

49

1 reference

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15 February 2020

issue

46

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20958061%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

page(s)

9972-9984

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20958061%20AND%20SRC:MED&resulttype=core&format=json

JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors

15 February 2020

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1 reference

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Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1

6 July 2018

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Recent developments on JAK2 inhibitors: a patent review.

6 July 2018

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Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

6 July 2018

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A regulating role of the JAK2 FERM domain in hyperactivation of JAK2(V617F).

6 July 2018

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Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening

6 July 2018

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Activation loop tyrosines allow the JAK2(V617F) mutant to attain hyperactivation

6 July 2018

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Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth

6 July 2018

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Clinical correlates of JAK2V617F presence or allele burden in myeloproliferative neoplasms: a critical reappraisal

6 July 2018

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Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera.

6 July 2018

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Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2.

6 July 2018

1 reference

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WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation

6 July 2018

1 reference

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Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders

6 July 2018

1 reference

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TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations

6 July 2018

1 reference

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JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.

6 July 2018

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Scalable molecular dynamics with NAMD

6 July 2018

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Identification of an acquired JAK2 mutation in polycythemia vera

6 July 2018

1 reference

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A gain-of-function mutation of JAK2 in myeloproliferative disorders

6 July 2018

1 reference

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

6 July 2018

1 reference

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

6 July 2018

1 reference

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Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders

6 July 2018

1 reference

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Jak2 tyrosine kinase: a true jak of all trades?

6 July 2018

1 reference

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UCSF Chimera--a visualization system for exploratory research and analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982877

Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982877

A possible role for pi-stacking in the self-assembly of amyloid fibrils

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982877

pi-Stacking interactions. Alive and well in proteins

6 July 2018

1 reference

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Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis

6 July 2018

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Jak2 is essential for signaling through a variety of cytokine receptors

6 July 2018

1 reference

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Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor

6 July 2018

1 reference

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Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

6 July 2018

1 reference

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6 July 2018

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JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982877

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

6 July 2018

1 reference

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Aromatic-aromatic interaction: a mechanism of protein structure stabilization

6 July 2018

1 reference

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Effects of the biological backbone on DNA-protein stacking interactions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982877

Tuning the thermodynamics of association of transmembrane helices.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982877

Mechanisms of constitutive activation of Janus kinase 2-V617F revealed at the atomic level through molecular dynamics simulations

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982877

The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982877

Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982877

Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2982877

Myeloproliferative disorders

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20958061

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hydrophilicity of cavities in proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20958061

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/BI1014858

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20958061%20AND%20SRC:MED&resulttype=core&format=json

release_e7ihhboasnchnasu2fc3csgjbu

15 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/e7ihhboasnchnasu2fc3csgjbu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20958061%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference